EFFECT OF NANDROLONE DECANOATE ON VOICE AND REPRODUCTIVE TISSUES IN WISTAR RAT: HISTOPATHOLOGICAL AND MORPHOMETRIC ASSESSMENT
Background:Nandrolone Decanoate (ND) artificial testosterone in the steroid forum is of significant effect essential in clinical settings for the treatment of chronic diseases. Its mechanism of action is apparent by binding to receptor complexes such as hormones producing anabolic and androgenic effects. Objectives:To research the effects of ND on the reproductive system of Adult Wistar rats as well as on the voice of female Wistar rats exposed to the physical and non-physical activity. Methods: In this experimental study, 12 models (6 males, 6 females) received 5mg/kg BW of DecaDurabolin base on their weight indicating a normal dose once a week for four weeks. The Active models were subjected to aerobic swimming as the physical activity. Results: Female voice sounds decrease progressively from a sharp whistle-like sound to blunt and finally dull sounds. Also, the histological analysis revealed that the inactive males were with reduced spermatogenic activities, hyperplasia of the interstitial cell of Leydig with congested blood vessels in the testis while the inactive female analysis revealed foci of congestion around the cortical and medullary regions of the ovary. The histological analysis of the active males revealed reduced germ cells in the seminiferous tubules, sloughing of the germinal epithelium and interstitial edema of the testis, while the ovary revealed well-defined blood vessels within the medulla and medullary congestion. Conclusion: Administrationof Nandrolone Decanoate was associated with deleterious effects on active and inactive models on the testis, ovaries,and, voice.
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