Effectiveness of Hybrid Nurse-Led Self-Management Education with a Digital Pocketbook on Medication Adherence and Blood Pressure Control among Patients with Hypertension: A Quasi-Experimental Study
DOI:
https://doi.org/10.31674/mjmr.2026.v010i04.03Abstract
Background: Sustained medication adherence and effective self-management are essential for hypertension control. This study examined the association between hybrid nurse-led self-management education incorporating a Digital Pocketbook and medication adherence and blood pressure outcomes among adults with hypertension. Methods: A non-randomized quasi-experimental study with a pretest–posttest control-group design involved 62 adults with hypertension at a primary healthcare facility in Central Java, Indonesia. Participants were allocated to an intervention group (n = 31) or control group (n = 31). The eight-week intervention combined individualized nurse-led education, a Digital Pocketbook, and weekly WhatsApp follow-up, while controls received routine care. Medication adherence was assessed using the eight-item Morisky Medication Adherence Scale (MMAS-8), and blood pressure was measured using standardized automated procedures. Analysis of covariance (ANCOVA) adjusted for baseline outcome values. Results: Compared with controls, the intervention group demonstrated higher medication adherence (adjusted mean difference = 2.18; 95% CI: 1.56–2.80), lower systolic blood pressure (−17.84 mmHg; 95% CI: −22.77 to −12.91), and lower diastolic blood pressure (−11.05 mmHg; 95% CI: −14.34 to −7.76). All comparisons were statistically significant (p < 0.001), including after Bonferroni correction. Conclusions: Hybrid nurse-led education incorporating a Digital Pocketbook was associated with improved self-reported medication adherence and reduced blood pressure over eight weeks. Larger randomized trials with objective adherence measures and longer follow-up are needed to establish effectiveness and sustainability.
Keywords:
Digital Pocketbook, Hypertension, Medication Adherence, Nurse-Led Education, Self-ManagementDownloads
References
Aji, P. T., Gabriel Ching, M. T., & Rizkasari, E. (2026). Digital pocketbook education with a nurse-led approach to improve hypertension self-management in primary care. Abdimas Umtas: Jurnal Pengabdian Kepada Masyarakat, 9(2), 857–868. https://doi.org/10.35568/abdimas.v9i2.7857
Andrade, C. (2021). The limitations of quasi-experimental studies, and methods for data analysis when a quasi-experimental research design is unavoidable. Indian Journal of Psychological Medicine, 43(5), 451–452. https://doi.org/10.1177/02537176211034707
Boima, V., Doku, A., Agyekum, F., Tuglo, L. S., & Agyemang, C. (2024). Effectiveness of digital health interventions on blood pressure control, lifestyle behaviours and adherence to medication in patients with hypertension in low-income and middle-income countries: A systematic review and meta-analysis of randomised controlled trials. e-Clinical Medicine, 69, 102432. https://doi.org/10.1016/j.eclinm.2024.102432
Bulto, L. N., Roseleur, J., Noonan, S., Pinero de Plaza, M. A., Champion, S., Dafny, H. A., Pearson, V., Nesbitt, K., Gebremichael, L. G., Beleigoli, A., Gulyani, A., Schultz, T., Hines, S., Clark, R. A., & Hendriks, J. M. (2024). Effectiveness of nurse-led interventions versus usual care to manage hypertension and lifestyle behaviour: A systematic review and meta-analysis. European Journal of Cardiovascular Nursing, 23(1), 21–32. https://doi.org/10.1093/eurjcn/zvad040
Byrne, R. A., Rossello, X., Coughlan, J. J., Barbato, E., Berry, C., Chieffo, A., Claeys, M. J., Dan, G.-A., Dweck, M. R., Galbraith, M., Gilard, M., Hinterbuchner, L., Jankowska, E. A., Jüni, P., Kimura, T., Kunadian, V., Leosdottir, M., Lorusso, R., Pedretti, R. F. E., . . . ESC Scientific Document Group. (2023). 2023 ESC guidelines for the management of acute coronary syndromes: Developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC). European Heart Journal, 44(38), 3720–3826. https://doi.org/10.1093/eurheartj/ehad191
Des Jarlais, D. C., Lyles, C., Crepaz, N., & the TREND Group. (2004). Improving the reporting quality of nonrandomized evaluations of behavioral and public health interventions: The TREND statement. American Journal of Public Health, 94(3), 361–366. https://doi.org/10.2105/AJPH.94.3.361
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2), 175–191. https://doi.org/10.3758/BF03193146
Friska, D., Kekalih, A., Runtu, F., Rahmawati, A., Ibrahim, N. A. A., Anugrapaksi, E., Utami, N. P. B. S., Wijaya, A. D., & Ayuningtyas, R. (2022). Health cadres empowerment program through smartphone application-based educational videos to promote child growth and development. Frontiers in Public Health, 10, 887288. https://doi.org/10.3389/fpubh.2022.887288
Hwang, M., & Chang, A. K. (2023). The effect of nurse-led digital health interventions on blood pressure control for people with hypertension: A systematic review and meta-analysis. Journal of Nursing Scholarship, 55(5), 1020–1035. https://doi.org/10.1111/jnu.12882
Khoiry, Q. A., Alfian, S. D., & Abdulah, R. (2022). Modifiable and non-modifiable factors associated with low awareness of hypertension treatment in Indonesia: A cross-sectional population-based national survey. Global Heart, 17(1), 56. https://doi.org/10.5334/gh.1143
Kurihara, C., Kerpel-Fronius, S., Becker, S., Chan, A., Nagaty, Y., Naseem, S., Schenk, J., Matsuyama, K., & Baroutsou, V. (2024). Declaration of Helsinki: Ethical norm in pursuit of common global goals. Frontiers in Medicine, 11, 1360653. https://doi.org/10.3389/fmed.2024.1360653
Ma, Y., Cheng, H. Y., Sit, J. W. H., & Chien, W. T. (2022). The effects of a smartphone-enhanced nurse-facilitated self-care intervention for Chinese hypertensive patients: A randomised controlled trial. International Journal of Nursing Studies, 134, 104313. https://doi.org/10.1016/j.ijnurstu.2022.104313
Lakens, D. (2013). Calculating and reporting effect sizes to facilitate cumulative science: A practical primer for t-tests and ANOVAs. Frontiers in Psychology, 4, 863. https://doi.org/10.3389/fpsyg.2013.00863
Mahmood, S., Jalal, Z., Hadi, M. A., Khan, T. M., Haque, M. S., & Shah, K. U. (2021). Prevalence of non-adherence to antihypertensive medication in Asia: A systematic review and meta-analysis. International Journal of Clinical Pharmacy, 43(3), 486–501. https://doi.org/10.1007/s11096-021-01236-z
Manortey, S., & Adamaley, S. (2021). Factors associated with noncompliance to hypertension treatment in adults in a district health facility in North Dayi in the Volta Region of Ghana. International Journal of Noncommunicable Diseases, 6(4), 199–205. https://doi.org/10.4103/jncd.jncd_51_21
McDonagh, S. T. J., Dalal, H., Moore, S., Clark, C. E., Dean, S. G., Jolly, K., Cowie, A., Afzal, J., & Taylor, R. S. (2023). Home-based versus centre-based cardiac rehabilitation. Cochrane Database of Systematic Reviews, 2023(10), CD007130. https://doi.org/10.1002/14651858.CD007130.pub5
Morgado, M., Botelho, J., Machado, V., Mendes, J. J., Adesope, O., & Proença, L. (2024). Video-based approaches in health education: A systematic review and meta-analysis. Scientific Reports, 14(1), 23651. https://doi.org/10.1038/s41598-024-73671-7
McEvoy, J. W., McCarthy, C. P., Bruno, R. M., Brouwers, S., Canavan, M. D., Ceconi, C., Christodorescu, R. M., Daskalopoulou, S. S., Ferro, C. J., Gerdts, E., Hanssen, H., Harris, J., Lauder, L., McManus, R. J., Molloy, G. J., Rahimi, K., Regitz-Zagrosek, V., Rossi, G. P., Sandset, E. C., . . . ESC Scientific Document Group. (2024). 2024 ESC guidelines for the management of elevated blood pressure and hypertension. European Heart Journal, 45(38), 3912–4018. https://doi.org/10.1093/eurheartj/ehae178
Niu, R., & Li, K. (2026). Systematic review of the impact of digital health technologies on blood pressure control and treatment adherence in young and middle-aged hypertensive patients. Frontiers in Cardiovascular Medicine, 13, 1708019. https://doi.org/10.3389/fcvm.2026.1708019
Noorollahi, Z., Shahshahani, M. S., Farajzadegan, Z., & Keshvari, M. (2025). Investigating the effects of implementing the family health nurse model on the self-management of elderly individuals with hypertension: A randomized controlled trial. BMC Primary Care, 26(1), 380. https://doi.org/10.1186/s12875-025-03097-1
Nzioki, J. M., & Korir, A. (2018). Effect of a community health worker led health education intervention on latrine coverage in Mwingi West Sub-County; Kenya: A quasi-experiment. American Journal of Public Health Research, 6(3), 134–138. https://doi.org/10.12691/ajphr-6-3-2
Parums, D. V. (2024). Editorial: The 2024 revision of the Declaration of Helsinki and its continued role as a code of ethics to guide medical research. Medical Science Monitor, 30, e947428. https://doi.org/10.12659/MSM.947428
Periyakaruppan, G. M., Rajendran, S. S., Venkatachalam, G. P., Parasuraman, A., Ramachandran, M., Ramakrishnan, G. S., & Dhakshnamoorthy, M. (2025). Effectiveness of nurse-led intervention on health risks in perimenopausal women: A mixed-methods study. Bioinformation, 21(8), 2421–2424. https://doi.org/10.6026/973206300212421
Sakinah, S., Dee, T. M. T., & Tusi, J. S. (2024). The effect of self-management education based on the health promotion model on compliance behavior of hypertension patients. Babali Nursing Research, 5(4), 768–782. https://doi.org/10.37363/bnr.2024.54431
Tsai, H. Y., Chuang, H. J., Liao, W. H., Wang, Y. J., Li, P. H., Wang, W. T., Liao, S. C., Yeh, C. F., Chen, P. R., Lai, T. H., Lin, H. J., Cheng, S. Y., Chen, W. J., Lin, Y. H., & Chang, Y. Y. (2025). Lifestyle modifications and non-pharmacological management in elderly hypertension. Journal of the Formosan Medical Association, 124(Suppl. 1), S32–S41. https://doi.org/10.1016/j.jfma.2024.10.022
Upoyo, A. S., Sari, Y., Taufik, A., Anam, A., & Kuswati, A. (2024). The effect of online group education on promoting knowledge, motivation, self-efficacy, self-care behaviors and preventing uncontrolled blood pressure in hypertensive patients: A quasi-experiment study. SAGE Open Nursing, 10, 23779608241299288. https://doi.org/10.1177/23779608241299288
World Health Organization. (2023). Global report on hypertension: The race against a silent killer. https://www.who.int/publications/i/item/9789240081062
Yang, S., Li, F., Thomas, L. E., & Li, F. (2021). Covariate adjustment in subgroup analyses of randomized clinical trials: A propensity score approach. Clinical Trials, 18(5), 570–581. https://doi.org/10.1177/17407745211028588
Zhang, W., Xu, R., Cai, Z., Zheng, X., Zheng, M., & Ni, C. (2023). Association between physical activity and resistant hypertension in treated hypertension patients: Analysis of the National Health and Nutrition Examination Survey. BMC Cardiovascular Disorders, 23(1), 289. https://doi.org/10.1186/s12872-023-03303-x
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Malaysian Journal of Medical Research (MJMR)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
























