To Compare the Clinical Efficacy and Safety of 20% Mandelic Acid Peel Versus 20% Arginine Peel in the Treatment of Peri-Orbital Hyperpigmentation - A Prospective Randomised Controlled Trial
DOI:
https://doi.org/10.31674/mjmr.2025.v09i04.004Abstract
Background: Periorbital hyperpigmentation (POH) is a very common, yet unexplored aesthetic condition. Topical therapy is mainstay of treatment which includes chemical peels. Objective: To compare the clinical efficacy and safety of 20% Mandelic acid peel versus 20% Arginine peel in the treatment of constitutional type of peri-orbital hyperpigmentation. Method: 24 patients of constitutional POH were enrolled for 12 weeks. They were divided into two groups of 12 each. In 1st group 20% Arginine peel and 2nd group 20% Mandelic peel sessions were performed at 3 weekly intervals. Clinical improvement was assessed objectively using POH grading, physician's and patient's global assessment, and patient's global tolerance. Results: Significant improvement in periorbital hyperpigmentation was noted in both the groups. Physician’s and patient's global assessment was excellent with mandelic peel as compared to arginine peel. The incidence of side effects in the form of erythema and itching was maximum with mandelic peel and least with Arginine peel, which did not necessitate cessation of therapy. Conclusion: Mandelic peel showed the better results among the two peels; however, Arginine peel emerged as a safe and effective modality for the treatment of POH.
Keywords:
Arginine Peel, Chemical Peeling, Mandelic Peel, Periorbital HyperpigmentationDownloads
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