A Comparative Study of the Efficacy of PRP Prepared Using Double Spin Technique versus PRP Prepared Using Turn Down – Turn Up (TD-TU) Technique in Combination with Microneedling in the Treatment of Atrophic Acne Scars
DOI:
https://doi.org/10.31674/mjmr.2024.v08i04.003Abstract
Background: Acne scarring has a huge impact on patient’s life. Platelet rich plasma (PRP) has been widely used as an adjunct to other procedures like microneedling in the treatment of acne scars. Aim: The aim of the study is to compare the efficacy of microneedling with PRP prepared using double spin technique and microneedling with PRP prepared using Turn down- Turn up technique in treating atrophic post acne scars. Methods: A total of 20 patients suffering from atrophic acne scars were included in the study and randomly divided into two groups of 10 each. Group A were treated with microneedling and PRP prepared using Double–spin technique and in Group B patients were treated with microneedling and PRP prepared using Turn down-Turn up technique (TD-TU). A total of 2 sittings were done at 4 weeks interval and the final readings were assessed after 8 weeks. The improvement in scars were evaluated using Goodman and Baron’s scale, ECCA scale, Scar quartile gradient and dermatology life quality index scores. Results were analysed using Mann-Whitney test and Wilcoxon signed rank test. Results: Significant improvement in the acne scars was noted in both the groups. Conclusion: Microneedling in combination with PRP prepared using Turn Down- Turn up technique produces appreciable results comparable to PRP prepared using double-spin technique in the management of atrophic acne scars.
Keywords:
Atrophic Acne Scars, Microneedling, Platelet Rich PlasmaDownloads
References
Amer, A., Elhariry, S., & Al-Balat, W. (2021). Combined autologous platelet-rich plasma with microneedling versus microneedling with non-cross-linked hyaluronic acid in the treatment of atrophic acne scars: Split-face study. Dermatologic Therapy, 34(1), e14457. https://doi.org/10.1111/dth.14457
Baldwin, H. E. (2002). The interaction between acne vulgaris and the psyche. Cutis-New York, 70(2), 133-139. Retrieved from: https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/070020133.pdf. Accessed on 25th May, 2024
Chandrashekar, B. S., Sriram, R., Mysore, R., Bhaskar, S., & Shetty, A. (2014). Evaluation of microneedling fractional radiofrequency device for treatment of acne scars. Journal of Cutaneous and Aesthetic Surgery, 7(2), 93–97. https://doi.org/10.4103/0974-2077.138328
Chawla, S. (2014). Split face comparative study of microneedling with PRP versus microneedling with vitamin C in treating atrophic post acne scars. Journal of Cutaneous and Aesthetic Surgery, 7(4), 209–212. https://doi.org/10.4103/0974-2077.150742
Choukroun, J., & Ghanaati, S. (2018). Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients' own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society, 44(1), 87–95. https://doi.org/10.1007/s00068-017-0767-9
Dogra, S., Yadav, S., & Sarangal, R. (2014). Microneedling for acne scars in Asian skin type: An effective low cost treatment modality. Journal of Cosmetic Dermatology, 13(3), 180–187. https://doi.org/10.1111/jocd.12095
Dreno, B., Khammari, A., Orain, N., Noray, C., Mérial-Kieny, C., Méry, S., & Nocera, T. (2007). ECCA grading scale: an original validated acne scar grading scale for clinical practice in dermatology. Dermatology (Basel, Switzerland), 214(1), 46–51. https://doi.org/10.1159/000096912
El-Domyati, M., Abdel-Wahab, H., & Hossam, A. (2018). Microneedling combined with platelet-rich plasma or trichloroacetic acid peeling for management of acne scarring: A split-face clinical and histologic comparison. Journal of Cosmetic Dermatology, 17(1), 73–83. https://doi.org/10.1111/jocd.12459
Elsaie, M. L., Ibrahim, S. M., & Saudi, W. (2018). Ablative fractional 10 600 nm Carbon Dioxide laser versus non-ablative fractional 1540 nm erbium-glass laser in Egyptian post-acne scar patients. Journal of lasers in Medical Sciences, 9(1), 32–35. https://doi.org/10.15171/jlms.2018.08
Fabbrocini, G., Fardella, N., Monfrecola, A., Proietti, I., & Innocenzi, D. (2009). Acne scarring treatment using skin needling. Clinical and Experimental Dermatology, 34(8), 874-879. https://doi.org/10.1111/j.1365-2230.2009.03291.x
Fernandes, D. (2002). Percutaneous collagen induction: An alternative to laser resurfacing. Aesthetic Surgery Journal, 22(3), 307–309. https://doi.org/10.1067/maj.2002.126195
Finlay, A. Y., & Khan, G. K. (1994). Dermatology Life Quality Index (DLQI) – A simple practical measure for routine clinical use. Clinical and Experimental Dermatology, 19(3), 210–216. https://doi.org/10.1111/j.1365-2230.1994.tb01167.x
Gadkari, R., & Nayak, C. (2014). A split-face comparative study to evaluate efficacy of combined subcision and dermaroller against combined subcision and cryoroller in treatment of acne scars. Journal of Cosmetic Dermatology, 13(1), 38–43. https://doi.org/10.1111/jocd.12071
Goodman, G. J., & Baron, J. A. (2006). Postacne scarring: A qualitative global scarring grading system. Dermatologic Surgery, 32(12), 1458-1466. https://doi.org/10.1111/j.1524-4725.2006.32354.x
Gupta, M., Barman, K. D., & Sarkar, R. (2021). A comparative study of microneedling alone versus along with platelet-rich plasma in acne scars. Journal of Cutaneous and Aesthetic Surgery, 14(1), 64–71. https://doi.org/10.4103/JCAS.JCAS_190_20
Hayashi, N., Miyachi, Y., & Kawashima, M. (2015). Prevalence of scars and "mini-scars", and their impact on quality of life in Japanese patients with acne. The Journal of Dermatology, 42(7), 690–696. https://doi.org/10.1111/1346-8138.12885
Hazarika, N., & Rajaprabha, R. K. (2016). Assessment of life quality index among patients with acne vulgaris in a suburban population. Indian Journal of Dermatology, 61(2), 163–168. https://doi.org/10.4103/0019-5154.177758
Ismail, S. A., Khella, N. A. H., & Abou-Taleb, D. A. E. (2022). Which is more effective in atrophic acne scars treatment microneedling alone or platelet rich plasma alone or combined both therapeutic modalities?. Dermatologic Therapy, 35(12), e15925. https://doi.org/10.1111/dth.15925
Kingsley, C. S. (1954). Blood coagulation: Evidence of an antagonist to factor VI in platelet-rich human plasma. Nature, 173(4407), 723-724. https://doi.org/10.1038/173723a0
Layton, A. M., Henderson, C. A., & Cunliffe, W. J. (1994). A clinical evaluation of acne scarring and its incidence. Clinical and Experimental Dermatology, 19(4), 303-308. https://doi.org/10.1111/j.1365-2230.1994.tb01200.x
Machado, E. S., Leite, R., Dos Santos, C. C., Artuso, G. L., Gluszczak, F., de Jesus, L. G., Caldas, J. M. P., & Bredemeier, M. (2019). Turn down - turn up: A simple and low-cost protocol for preparing platelet-rich plasma. Clinics (Sao Paulo, Brazil), 74, e1132. https://doi.org/10.6061/clinics/2019/e1132
Marx, R. E. (2001). Platelet-rich plasma (PRP): what is PRP and what is not PRP?. Implant Dentistry, 10(4), 225–228. https://doi.org/10.1097/00008505-200110000-00002
Nandini, A. S., Sankey, S. M., Sowmya, C. S., & Sharath Kumar, B. C. (2021). Split-face comparative study of efficacy of platelet-rich plasma combined with microneedling versus microneedling alone in treatment of post-acne scars. Journal of Cutaneous and Aesthetic Surgery, 14(1), 26–31. https://doi.org/10.4103/JCAS.JCAS_160_18
Poli, F., Dreno, B., & Verschoore, M. (2001). An epidemiological study of acne in female adults: Results of a survey conducted in France. Journal of the European Academy of Dermatology and Venereology: JEADV, 15(6), 541–545. https://doi.org/10.1046/j.1468-3083.2001.00357.x
Porwal, S., Chahar, Y. S., & Singh, P. K. (2018). A comparative study of Combined Dermaroller and Platelet-Rich Plasma Versus Dermaroller alone in acne scars and assessment of quality of life before and after treatment. Indian Journal of Dermatology, 63(5), 403–408. https://doi.org/10.4103/ijd.IJD_118_17
Sharad, J. (2011). Combination of microneedling and glycolic acid peels for the treatment of acne scars in dark skin. Journal of Cosmetic Dermatology, 10(4), 317–323. https://doi.org/10.1111/j.1473-2165.2011.00583.x
Singh, A., & Yadav, S. (2016). Microneedling: Advances and widening horizons. Indian Dermatology Online Journal, 7(4), 244–254. https://doi.org/10.4103/2229-5178.185468
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