• Ashmita Das Department of zoology, Serampore College, Calcutta University, India


The objective of present day study was to assess relationship between biomarkers of manganese and neuropsychological effects. Manganese (Mn) is an essential element for many biological functions in human beings. However, overexposure to manganese can causes health problems especially neurotoxicity. Mn accumulates in the brain regions and it cause central nervous system (CNS) abnormality and neuropsychiatric disorder. The respiratory system is the most important way of Mn absorption for workers in Mn related industries. Welders are exposed to relatively high concentrations of manganese and while the neurotoxicity of manganese is well documented, few studies have investigated the cardiac effects of occupational manganese exposures. By examining electrograms (ECG) and heart rate variability (HRV), the cardiac conditions among the welders are clearly determined. Blood, nails, hairs were taken as biomarker. But the most suitable biomarker is hair because of its slow growth rates, less influenced by short term variability of manganese exposure levels.  


Manganese, Occupational exposure, Ecocardiogram, Biomarkers, Neuropsychiatric disorder


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Cowan, D.M., Fan, Q., Zou, Y., Shi, X., Chen, J., Aschhner, M., Rosenthal, F.S. & Zheng, W. (2009). Manganese exposure among smelting workers: blood manganese iron ratio as a novel tool for manganese exposure assessment. Biomarkers, 14(1), pp 3-16.

Elingsen, D. G., Heltland, S.M. & Thomassen, Y., (2003). Manganese air exposure assessment and biological monitoring in manganese alloy production industries. Journal of Environmental Monitoring, 5(1), pp 84-90.

Franco, M.C., Dantas, A.P., Akamine, E.H., Kawamoto, E.M., Fortes, Z.B., Scavone, C., Tostes, R.C., Carvalho, M.H. & Nigro, D. (2002). Enhanced oxidative stress as a potential mechanism underlying the programming of hypertension in utero. Journal of Cardiovascular Pharmacology, 40(4), pp 501–509

Hassani, H., Golbabaei, F., Ghahri, A., Hosseini, M., Shirkhanloo, H., Dinari, B., Eskandari, D. & Fallahi, M. (2012). Occupational exposure to manganesecontaining welding fumes and pulmonary functions indices among natural gas transmission pipelines welders. Journal of occupational health, 54(4), pp 316-22.

He, S.C., Niu, Q., Wang, S., Chen, Y.L., Li, H.Y. & Wang, J.Y. (2002). Alteration of cardiovascular autonomic nervous system in welding workers. Chinese Journal

of Environmental and Occupational Medicine, 19, pp 371–373.

Jiang, Y.M., Lu, J.P., Lu, Z.G. & Huang, J.L. (1999). Effects of manganese exposure on female workers' cardiovascular functions. Railway Occupational Safety Health & Environmental Protection, 26, pp 31–33.

Lu, JF. (1989). Applied value on cardiac STI in the examination of the workers exposed to lead, benzene and manganese. Guangxi Occupational prevention. 1989, pp 66

Magari, S.R., Schwartz, J., Williams, P.L., Hauser, R., Smith, T.J. & Christiani, D.C. (2002). The

association of particulate air metal concentrations with heart rate variability. Environmental Health Perspective, 110(9), pp 875–880.

Reaney, S.H. & Smith, D.R. (2005). Manganese oxidation state mediates toxicity in PC12 cells. Toxicology and Applied Pharmacology, 205(3), pp 271–281.

R o d r i g u e s E . G . , K i l e , M . , D o b s o n , C . , Amarasiriwardan C., Quamruzzaman, Q., Rahman, M., Golam, M. & Christiani D.C., (2015). Maternal–infant biomarkers of prenatal exposure to arsenic and manganese. Journal of Exposure Science and Environmental Epidemiology, 25(6), pp 639-648.

Smith, D., Gwiazda, R., Bowler, R., Roels, H., Park, R., Taicher, C. & Lucchini, R. (2007). Biomarkers of Mn exposure in humans. American Journal of Industrial Medicine, 50(11), pp 801-11.

Su, D.M., Li, J.Y., Liu, S.Z. & Guo, G.X. (1998). Investigation on health in manganese ferroalloy workers. Journal of Occupational. Health Emergency Rescue, 16, pp 148–149.

Sun, G.F. (2003) Manganese. In: Jin, TY.; Sun, GF., editors. Journal of Occupational Health and Occupational Medicine, 5th Edition, People's educational press, Beijing, pp 175-176.




How to Cite

Ashmita Das. (2017). BIOMARKERS FOR MANGANESE EXPOSURE AMONG WELDERS AND CARDIOVASCULAR TOXICITIES . Malaysian Journal of Medical Research (MJMR), 1(4), 51-54. Retrieved from