IS THERE ANY ROLE OF METAL TOXICITY IN AMENORRHEA?
Abstract
Introduction: Metal toxicity has played an important role in many diseases. Apart from cancers, it is proven to be toxic in various system dysfunctions like teratogenicity, various tissue disorders and organ failures. Lead, mercury and cadmium are already proven reproductive toxicants. Since West Bengal is the most arsenic prone state in India, arsenic is the selected metal in our study, to find any association with amenorrhea.
Objectives: Objective of this study is to find out any possible correlation between arsenic toxicity and causation of amenorrhea in population of West Bengal.
Methodology: Ethical clearance from the institutional committee has been obtained for this study. Patients attending the genetics Out Patient Department of our hospital referred from different hospitals were screened for amenorrhea. Detailed clinical features and lifestyle history were recorded with expert opinion of clinician. In this study, 20 healthy females were selected as control. Peripheral venous blood and hair samples were taken with their proper consent for human leukocyte culture and arsenic estimation, the latter performed by flow injection hydride generation atomic absorption spectrometry. Karyotyping was done for chromosomal analysis.
Result: Among 50 amenorrhea patients of different chromosomal profile 14 patients showed elevated arsenic level above safe limit (0.8µg/g). Whereas only 2 control individual showed arsenic count above safe limit.
Conclusion: Other metals like lead, cadmium, mercury are proven toxicants for Human reproductive and endocrine systems and potential cause for infertility. In our study the amenorrhea patients showed significantly high arsenic count than control individual. Thus we can conclude that arsenic may have an association with amenorrhea
Keywords:
Amenorrhrea, Karyotyping, Metal Toxicity, Arsenic, West BengalDownloads
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