A COMPARATIVE STUDY OF DIFFERENT RISK FACTORS WITH ORAL CARCINOMA- IN SPECIAL REFERENCE WITH ARSENIC TOXICITY
Abstract
Introduction: Oral cancer ranks sixth among all the cancers worldwide. West Bengal being the most arsenic affected state in India, arsenic toxicity is also important in this carcinogenesis, which can be detected through micronuclei (MN) assay.
Objective: The objective of this study is to find out a possible correlation between arsenic toxicity and the development of this disease, assessing it through MN assay.
Methods: In this study, 104 oral malignant, 103 premalignant, 101 post operative cases along with 100 controls were included. The collected hair samples were processed for arsenic estimation by flow injection hydride generation atomic absorption spectrometry and the buccal smear samples were Giemsa stained and observed under microscope for calculating MN frequency.
Results: 67% of malignant, 54% of premalignant, 66% of post operative cases while only 4% of controls showed their arsenic count above the safe limit. The MN frequency was highest in malignant cases, but it was negligible in healthy controls.
Conclusion: A considerable percentage of cases showing higher arsenic count than controls may indicate a possible impact of arsenic toxicity on oral cancer, also detected through the significant difference of MN frequencies among the groups
Keywords:
Arsenic, Oral cancer, West Bengal, MicronucleiDownloads
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