BACCAUREA ANGULATA FRUIT JUICE PROTECTS RABBIT’S LIVER FROM HYPERCHOLESTEROLEMIA-INDUCED INJURY
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome strongly associated with hyperlipidemia, hypertriglyceridemia, insulin resistance and obesity. The objective of this study is to evaluate the potential health benefits of Baccaurea angulata fruit in preventing liver damage due to hypercholesterolemia. Twenty-five healthy adult New Zealand White rabbits were assigned to five groups for 90 days diet and intervention plan. While four groups (atherogenic groups) were fed 1% cholesterol diet and 0, 0.5, 1.0, and 1.5 mL of B. angulata juice per kg per day, the fifth group (negative control) was fed with commercial rabbit pellet only. After overnight fasting and sacrifice, the thoracic cavity was opened and the liver was carefully removed, specifically observing for any presence of a gross lesion and then immediately fixing in 4% paraformaldehyde for at least 48 hours for histopathological analysis. The hepatoprotective effect of B. angulata fruit juice was evident in the histological examination of liver tissues. The results indicate the potential health benefits of the antioxidant-rich B. angulata fruit juice as a functional food with a therapeutic effect against hypercholesterolemia-induced liver injury.
Keywords:
Atherosclerosis, b. angulata, Hypercholesterolemia, Non-alcoholic fatty liver diseaseDownloads
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