CANDIDA HAEMULONII IN BLOOD -- A NEW CHALLENGE
Abstract
Currently, a series of cases with invasive Candida haemulonii is occurring and this is an emerging yeast pathogen for which the optimal strategy of patient management has yet to be elucidated. In this study, blood culture was done from clinical sepsis cases by BACTEC method. Yeast isolates were identified by Gram staining, germ tube test and colony morphology. Antifungal susceptibility was determined by MIC value. DNA sequencing of the strains were also performed. Candida haemulonii was isolated in 8 cases from November 2014 to August 2015. All isolates showed high level resistance to Amphotericin B, variable resistance to Flucytosine and Fluconazole, susceptibility to Echinocandins and Voriconazole. Majority of the cases had central venous catheter, prolonged broad-spectrum antimicrobial use and two also had parenteral nutrition. While, 2 cases were successfully treated with Caspofungin and Voriconazole, 4 patients could not survive but showed some improvement both by clinical and sepsis marker study (CRP, procalcitonin) with initiation of antifungal treatment. DNA sequencing showed that the isolates were Candida auris. Thus, clinically the impact of this species has been attained to some extent in this study which is immensely vital considering the very high mortality rate.
Keywords:
Candida haemulonii, Yeast, MIC, Antifungal treatmentDownloads
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