EVALUATION OF ROLE OF SUPEROXIDE DISMUTASE IN NON-TOXIC THYROID NODULES
Thyroid epithelial cells produce moderate amounts of Reactive Oxygen Species (ROS) under normal conditions that are physiologically required for the synthesis of thyroid hormones. However, in case of a diseased thyroid gland they may be produced in amounts much higher than normal. This excess production of ROS can cause an oxidant/antioxidant imbalance resulting in oxidative stress and damage of cells. The human antioxidant defense mechanism consists of various enzymatic and non-enzymatic components which are responsible for the quenching of ROS.The present study is aimed at comparing the activity of antioxidant enzyme- Superoxide Dismutase (SOD) from blood of patients with benign and malignant thyroid nodules of non-toxic group and healthy controls in order to evaluate the possibility of presence of excess oxidative stress and its role in development of thyroid cancer.
Keywords:Oxidative stress, Superoxide dismutase, Thyroid cancer
Albores-Saavedra, J., Henson, D. E., Glazer, E. & Schwartz , A. M. (2007). Changing patterns in the
incidence and survival of thyroid cancer with follicular phenotype—papillary, follicular, and
anaplastic: a morphological and epidemiological study. Endocrine Pathology, 18(1), pp 1–7.
Bankson, D.D., Kestin, M. & Rifai, N. (1993). Role of free radicals in cancer and atherosclerosis. Clinics in Laboratory Medicine, 13(2), pp 463-80.
Barroeta, J.E., Wang, H., Shiina, N., Gupta, P.K., Livolsi, V.A. & Baloch, Z.W. (2006). Is fine-needle aspiration (FNA) of multiple thyroid nodules justified? Endocrine Pathology, 17(1), pp 61–5.
Davies, L. & Welch, H. G. (2006). Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA, 295(18), pp 2164–2167.
Durak, I., Bayram, F., Kavutcu, M., Canbolat, O. & Öztürk, S. (1996). Impaired enzymatic antioxidant defense mechanism in cancerous human thyroid tissues. Journal of Endocrinological Investigation, 19(5), pp 312-5
Felt, V., Cerný, K., Klímová, H., Kŕemenová, J. & Rehák, F. (1976). Enzyme changes in thyroid tissue
with reference to thyroid cancer. Acta Universitatis Carolinae Medica (Praha), 22(7-8), pp 435-42.
Fujita, T. (2002). Formation and Removal of Reactive Oxygen Species, Lipid Peroxides and Free Radicals, and Their Biological Effects. Yakugaku Zasshi - Journal of the Pharmaceutical Society of
Japan, 122(3), pp 203-218.
Gharib H, Papini E, Paschke R, Duick DS, Hegedus L, Vitti, P., AACE/AME/ETA Task Force on Thyroid
Nodules (2010). American Association of Clinical Endocrinologists, Associazione Medicie Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. Endocrine Practice, 16(3), pp 468-75
Hodgson, N. C., Button, J. & Solorzano, C.C. (2004).Thyroid cancer: is the incidence still increasing? Annals of Surgical Oncology, 11(12), pp 1093–1097.
Oberley, L.W. & Oberley, T.D. (1984). The role of superoxide dismutase and gene amplification in
carcinogenesis. Journal of Theoretical Biology, 106(3), pp 403-422.
Marklund, S. & Marklund, G. (1974). Involvement of the Superoxide Anion Radical in the Autoxidation
of Pyrogallol and a Convenient Assay for Superoxide Dismutase. European Journal of Biochemistry, 47(3), pp 469–474.
Polyzos, S.A., Kita, M. & Avramidis, A. (2007) Thyroid nodules-Stepwose diagnosis and management. Hormones (Athens), 6(2), pp 101–119
Poncin, S., Van Eeckoudt, S., Humblet, K., Colin, I.M. & Gérard, A.C. (2010). Oxidative stress: a required condition for thyroid cell proliferation. The American journal of pathology, 176(3), pp 1355-63.
Sadani, G.R. & Nadkarni, G.D. (1996). Role of tissue antioxidant defence in thyroid cancers. Cancer
Letters, 109(1-2), pp 231-235.
Yanagawa, T., Ishikawa, T., Ishii, T., Tabuchi, K., Iwasa, S., Bannai, S., Omura, K., Suzuki, H. &
Yoshida, H. (1999). Peroxiredoxin I expression in human thyroid tumors. Cancer Letters,145(1-2), pp 127-32.
How to Cite
Copyright (c) 2017 Malaysian Journal of Medical Research (MJMR)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.