EVALUATION OF ROLE OF SUPEROXIDE DISMUTASE IN NON-TOXIC THYROID NODULES
Abstract
Thyroid epithelial cells produce moderate amounts of Reactive Oxygen Species (ROS) under normal conditions that are physiologically required for the synthesis of thyroid hormones. However, in case of a diseased thyroid gland they may be produced in amounts much higher than normal. This excess production of ROS can cause an oxidant/antioxidant imbalance resulting in oxidative stress and damage of cells. The human antioxidant defense mechanism consists of various enzymatic and non-enzymatic components which are responsible for the quenching of ROS.The present study is aimed at comparing the activity of antioxidant enzyme- Superoxide Dismutase (SOD) from blood of patients with benign and malignant thyroid nodules of non-toxic group and healthy controls in order to evaluate the possibility of presence of excess oxidative stress and its role in development of thyroid cancer.
Keywords:
Oxidative stress, Superoxide dismutase, Thyroid cancerDownloads
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