Vacuum-Assisted Wound Dressing for Shorter Wound Healing Time: A Meta-Analysis


  • Sim Chap Hoong Lincoln University College, Selangor D. E., Malaysia
  • Vickneswaran Loganathan Lincoln University College, Selangor D. E., Malaysia
  • Regidor III Dioso Lincoln University College, Selangor D. E., Malaysia


Background: Vacuum-assisted wound dressing consists of a vacuum/suction machine, a conduction hose, a suction portal, foam/gauze, and an air-tight membrane, a method that is more technical but needs proper user training prior to application of the dressing. Methods: The population (P), intervention (I), and outcome (O) frameworks were used in this search strategy with keywords. The data extraction technique used the PRIMA guidelines with inclusion and exclusion criteria guided by the PIO framework. The quality of studies was assessed using appraisal tools for randomised controlled trials. A forest plot was used to illustrate the overall outcome in a random effect model. Out of 66 total articles extracted from databases, only five studies were used. Conclusion: Vacuum-assisted wound dressing showed no significant improvement in healing time compared to normal saline dressing (1.0).


Vacuum-assisted wound dressing, negative pressure wound therapy, improved wound healing time


Download data is not yet available.


Agarwal, P., Kukrele, R., & Sharma, D. (2019). Vacuum assisted closure (VAC)/negative pressure wound therapy (NPWT) for difficult wounds: A review. Journal of Clinical Orthopaedics and Trauma, 10(5), 845–848.

Critical Appraisal Skills Programme. (2018). CASP (Randomized Controlled Trial) Checklist. CASP Publishing.

Franco-Buenaventura, D., & García-Perdomo, H. A. (2021). Vacuum-assisted closure device in the postoperative wound care for Fournier’s gangrene: a systematic review. International Urology and Nephrology, 53(4), 641–653.

Janugade, H. B., Chabbra, R. S., Das, A. G., Surushe, A., & Saygaonkar, H. (2018). Outcomes of VAC versus conventional dressings in patients with lower limb ulcer. International Surgery Journal, 5(5), 1792.

Ji, S., Liu, X., Huang, J., Bao, J., Chen, Z., Han, C., Hao, D., Hong, J., Hu, D., Jiang, Y., Ju, S., Li, H., Li, Z., Liang, G., Liu, Y., Luo, G., Lv, G., Ran, X., Shi, Z., … Xia, Z. (2021). Consensus on the application of negative pressure wound therapy of diabetic foot wounds. Burns & Trauma, 9(1), tkab018.

Kumaar, A., Shanthappa, A. H., & Ethiraj, P. (2022). A Comparative Study on Efficacy of Negative Pressure Wound Therapy Versus Standard Wound Therapy for Patients With Compound Fractures in a Tertiary Care Hospital. Cureus, 14(4), e23727.

Mooghal, M., Usman, M., Khan, W., Brohi, L. B., Ahmad, A., & Rahim, K. (2021). Comparison of the mean healing time of wound after vacuum assisted closure versus conventional dressing in diabetic foot ulcer patients. International Journal of Clinical Trials, 8(4), 273.

Pragadheeswaran, M., Sankar lingam, P., Balan, Y., & Pyati, A. K. (2022). A Comparative Study Between Vacuum Dressing and Normal Saline Dressing for Chronic Non-Healing Ulcers. Cureus, 14(4), e23870.

Selcuk, A. A. (2019). A Guide for Systematic Reviews: PRISMA. Turkish Archives of Otorhinolaryngology, 57(1), 57–58.

Sirisena, R., Bellot, G. L., & Puhaindran, M. E. (2019). The Role of Negative-Pressure Wound Therapy in Lower-Limb Reconstruction. Indian Journal of Plastic Surgery, 52(01), 073–080.

Tuncel, U., Erkorkmaz, Ü., & Turan, A. (2013). Clinical evaluation of gauze-based negative pressure wound therapy in challenging wounds. International Wound Journal, 10(2), 152–158.

Yadav, S., Rawal, G., & Baxi, M. (2017). Vacuum assisted closure technique: a short review. Pan African Medical Journal, 28, 246.

Yang, Y., Liu, M., Yang, F., Wang, X., Bai, X., Mu, S., Liu, Y., & Hu, D. (2022). Circular RNA expression profiles following negative pressure wound therapy in burn wounds with experimental Pseudomonas aeruginosa infection. Bioengineered, 13(2), 4122–4136.



How to Cite

Hoong, S. C., Loganathan, V. ., & Dioso, R. I. (2022). Vacuum-Assisted Wound Dressing for Shorter Wound Healing Time: A Meta-Analysis. Malaysian Journal of Medical Research (MJMR), 6(4), 20-25. Retrieved from