NON-DIPHTHERIAE CORYNEBACTERIUM SPECIES AS EMERGING PATHOGENS: CASE SERIES FROM A TERTIARY CARE HOSPITAL IN WESTERN NEPAL

Authors

  • Niranjan Nayak Department of Microbiology, Manipal College of Medical Sciences, Nepal
  • Ranjana Parajuli Department of Microbiology, Manipal College of Medical Sciences, Nepal
  • Deependra Hamal Department of Microbiology, Manipal College of Medical Sciences, Nepal
  • Rajani Shrestha Department of Microbiology, Manipal College of Medical Sciences, Nepal
  • Sweekrity Neupane Department of Microbiology, Manipal College of Medical Sciences, Nepal
  • D. R. Bhatta Department of Microbiology, Manipal College of Medical Sciences, Nepal
  • Supram HS Department of Microbiology, Manipal College of Medical Sciences, Nepal
  • S Gokhale Department of Microbiology, Manipal College of Medical Sciences, Nepal
  • Binita Sharma Department of Microbiology, Manipal College of Medical Sciences, Nepal
  • Nisha Baral Department of Microbiology, Manipal College of Medical Sciences, Nepal

Abstract

Background: Corynebacteria other than C diphtheriae are often regarded as commensals of the skin and mucosa. However, these Corynebacterium species were recently recognized as emerging pathogens, causing systemic infections. Six cases due to non-diphetherial Corynebacteria as primary pathogens are reported here. 
Methods: This was an observational study. Therapeutic outcome along with demographic and clinical details were obtained from the patients’ records. Organisms were identified and antibiotic sensitivity testing was performed by conventional techniques.
Results: C. xerosis was isolated from three patients: one with non-healing wound over the face following scald injury; second, a post-operative wound infection; and third, a case of neonatal sepsis. Two cases with acute exacerbation of COPD (case 3 and 5), yielded C bovis and Corynebacterium spp. respectively. The later had a prolonged hospital stay showing concurrent infections with Acinetobacter and Candida spp. C falsenii, an unusual pathogen was recovered from blood of a 2 year septicemic child . The patients responded to appropriate antibiotic therapy and made substantial recovery.
Conclusions: This case series highlights the importance of non C. diphtheriae  Corynebacteria  as primary pathogens. Non-diphtherial Corynebacteria should not be discarded as commensals or contaminants. Timely identification, proper clinical correlation and appropriate therapeutic intervention can lead to favorable outcome.

Keywords:

Non-diphtherial Corynebacteria, COPD, Sepsis, Wound infection

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Published

2017-01-02

How to Cite

Niranjan Nayak, Ranjana Parajuli, Deependra Hamal, Rajani Shrestha, Sweekrity Neupane, D. R. Bhatta, Supram HS, S Gokhale, Binita Sharma, & Nisha Baral. (2017). NON-DIPHTHERIAE CORYNEBACTERIUM SPECIES AS EMERGING PATHOGENS: CASE SERIES FROM A TERTIARY CARE HOSPITAL IN WESTERN NEPAL. Malaysian Journal of Medical Research (MJMR), 1(1), 19-24. Retrieved from https://ejournal.lucp.net/index.php/mjmr/article/view/105