The Role of Nurse-led Health Education in Enhancing Treatment Adherence among Hemodialysis Patients: A Randomized Controlled Trial
DOI:
https://doi.org/10.31674/mjn.2026.v17i04.005Abstract
Background: For patients with end-stage renal disease, hemodialysis may be the only way to sustain life. However, it requires strict adherence to treatment to avoid its biopsychosocial burdens. Objectives: This study aims to estimate the efficacy of nursing health education based on the Theory of Planned Behavior (TPB) in improving treatment adherence among hemodialysis patients. Methods: This randomized controlled trial study involved 60 hemodialysis patients from the dialysis center of Telafer General Hospital, Nineveh, Iraq, from October 2024 to May 2025. The study participants were randomly divided into two groups (experimental group = 30 subjects and control group = 30 subjects). A specialized questionnaire consisting of the End-Stage Renal Disease-Adherence Questionnaire (ESRD-AQ) and TPB constructs scale was used in pre- and post-intervention tests to determine changes in adherence behavior, knowledge/perception, and TPB constructs over three time points (T0, T1, T2). Data was analyzed by descriptive and inferential statistics using the Statistical Package for Social Science (SPSS) software. Results: Most participants were in the age group of 60–69 years (21.7%). Statistically significant positive changes were noted among experimental group participants’ adherence behavior, knowledge/perceptions, and TPB constructs at post-tests 1 and 2 (p < 0.05). Intention was associated with attitude and perceived behavioral control (r = 0.442, 0.471; p < 0.05), respectively. In addition, intention was associated with treatment adherence behavior (r = 0.391). No significant changes or correlations in the study variables were observed among the control group participants over time. Conclusion: This study suggests that nursing health education based on TPB effectively improves treatment adherence among hemodialysis patients.
Keywords:
Chronic Kidney Disease; , End-Stage Renal Disease; , Hemodialysis;, Nursing Health Education; , Theory of Planned BehaviorDownloads
References
Abdul-Jabbar, M. A., & Kadhim, D. J. (2022). Adherence to different treatment modalities among patients on maintenance hemodialysis. Iraqi Journal of Pharmaceutical Sciences, 31(1), 95–101. https://doi.org/10.31351/vol31iss1pp95-101
Ajzen, I. (2020). The theory of planned behavior: Frequently asked questions. Human Behavior and Emerging Technologies, 2(4), 314–324. https://doi.org/10.1002/hbe2.195
Alenezi, W. A. D., Alomran, R. A., Alshlagi, N. S., Alenezi, M. A. D., Alrashedi, A. A., Alshammari, R. W., Alshammari, M. F., Alenezi, W. A. D., Al Zahrani, A. M. A., Alzahrani, M. J. A., & Aljuwaie, N. M. (2024). The role of nursing in enhancing the quality of life for hemodialysis patients. Journal of Ecohumanism, 3(8), 14109–14114. https://doi.org/10.62754/joe.v3i8.6607
Al-Khattabi, G. (2020). Factors affecting non-adherence to treatment of hemodialysis patients in Makkah City, Kingdom of Saudi Arabia. International Journal of Modern Trends in Social Sciences, 3(14), 21–38. https://gaexcellence.com/ijmtss/article/view/742
Asadizaker, B., Gheibizadeh, M., Ghanbari, S., & Araban, M. (2022). Predictors of Adherence to Treatment in Hemodialysis Patients: A Structural Equation Modeling. Medical Journal of the Islamic Republic of Iran, 36, 23. https://doi.org/10.47176/mjiri.36.23
Asare, M. (2015). Using the theory of planned behavior to determine the condom use behavior among college students. American Journal of Health Studies, 30(1), 43–50. https://doi.org/10.47779/ajhs.2015.168
Baktash, M. Q., & Aziz, A. A. (2023). Women’s knowledge of sexually transmitted diseases in Telafer City, Iraq. Nurse Media Journal of Nursing, 13(1), 12–21. https://doi.org/10.14710/nmjn.v13i1.48924
Baktash, M. Q., & Sulaiman, A. I. (2024). The analysis of hypertension knowledge in adults in Telafer City for health education and intervention. Journal of Angiotherapy, 8(2), 1–6. https://doi.org/10.25163/angiotherapy.829474
Bazrafshan, F. D., Darvizeh, Z., & Banijamali, S. S. (2023). The relationship between hemodialysis patients’ treatment adherence, procrastination, and difficulty in emotion regulation: A cross-sectional study in southeast Iran. Frontiers in Psychology, 13, 1041912. https://doi.org/10.3389/fpsyg.2022.1041912
Coimbra, S., & Santos-Silva, A. (2025). New advances in chronic kidney disease: Biology, diagnosis and therapy. Biomedicines, 13(2), 518. https://doi.org/10.3390/biomedicines13020518
Dsouza, B., Prabhu, R., Unnikrishnan, B., Ballal, S., Mundkur, S. C., Chandra Sekaran, V., Shetty, A., & Moreira, P. (2023). Effect of educational intervention on knowledge and level of adherence among hemodialysis patients: A randomized controlled trial. Global Health, Epidemiology and Genomics, 1, 4295613. https://doi.org/10.1155/2023/4295613
Gamal, S., Elseasi, A. M. A., Sabry, N. A., & Farid, S. F. (2025). Impact of pharmacist led mobile application on medication adherence and efficacy in chronic kidney disease. NPJ Digital Medicine, 8(1), 325. https://doi.org/10.1038/s41746-025-01742-8
Hagger, M. S., & Hamilton, K. (2025). Progress on theory of planned behavior research: Advances in research synthesis and agenda for future research. Journal of Behavioral Medicine, 48(1), 43–56. https://doi.org/10.1007/s10865-024-00545-8
Hopewell, S., Chan, A. W., Collins, G. S., Hróbjartsson, A., Moher, D., Schulz, K. F., Tunn, R., Aggarwal, R., Berkwits, M., Berlin, J. A., Bhandari, N., Butcher, N. J., Campbell, M. K., Chidebe, R. C. W., Elbourne, D., Farmer, A., Fergusson, D. A., Golub, R. M., Goodman, S. N., Hoffmann, T. C., … Boutron, I. (2025). CONSORT 2025 statement: updated guideline for reporting randomised trials. BMJ, 389, e081123. https://doi.org/10.1136/bmj-2024-081123
Irajpour, A., Hashemi, M. S., Abazari, P., & Shahidi, S. (2024). The effects of peer education on treatment adherence among patients receiving hemodialysis: A randomized controlled trial. Iranian Journal of Nursing and Midwifery Research, 29(1), 46–55. https://doi.org/10.4103/ijnmr.ijnmr_155_22
Javaran, E. J., Sharifi, H., Hasani, M., Borhaninejad, V., & Iranpour, A. (2020). Effectiveness of a theory of planned behavior-based intervention for promoting medication adherence among rural elderly hypertensive patients in Iran. Elderly Health Journal, 6(1), 9–15. https://doi.org/10.18502/ehj.v6i1.3410
Kamyab, A., Bijani, M., Jormand, H., Harsini, P. A., & Jeihooni, A. K. (2024). Education based on the theory of planned behavior to improve medication regimen adherence, hope and marital quality in patients with substance use disorder. BMC Public Health, 24(1), 3173. https://doi.org/10.1186/s12889-024-20651-1
Kim, Y., Evangelista, L. S., Phillips, L. R., Pavlish, C., & Kopple, J. D. (2010). The End-Stage Renal Disease Adherence Questionnaire (ESRD-AQ): Testing the psychometric properties in patients receiving in-center hemodialysis. Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association, 37(4), 377–393.
Naskar, S. T., & Lindahl, J. M. M. (2026). Forty years of the theory of planned behavior: a bibliometric analysis (1985–2024). Management Review Quarterly, 76(1), 573-632. https://doi.org/10.1007/s11301-025-00487-8
Paneerselvam, G. S., Lua, P. L., Chooi, W. H., Rehman, I. U., Goh, K. W., & Ming, L. C. (2025). Effectiveness of mobile apps in improving medication adherence among chronic kidney disease patients: Systematic review. Journal of Medical Internet Research, 27, e53144. https://doi.org/10.2196/53144
Pereira, D. G., Afonso, A., & Medeiros, F. M. (2015). Overview of Friedman’s Test and Post-hoc Analysis. Communications in Statistics - Simulation and Computation, 44(10), 2636-2653. https://doi.org/10.1080/03610918.2014.931971
Rich, A., Brandes, K., Mullan, B., & Hagger, M. S. (2015). Theory of planned behavior and adherence in chronic illness: A meta-analysis. Journal of Behavioral Medicine, 38(4), 673–688. https://doi.org/10.1007/s10865-015-9644-3
Sassen, B. (2023). Nursing Process and Health Promotion and Disease Prevention. In Nursing: Health Education and Improving Patient Self-Management: Intervention Mapping for Healthy Lifestyles (pp. 319-332). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-031-11255-3_20
Sheikh, V., Barati, M., Khazaei, S., & Jormand, H. (2022). Factors related to treatment adherence behaviors among old-age hemodialysis patients in Hamadan, Iran: The application of the extended theory of planned behavior during Covid-19 pandemic. BMC Nephrology, 23(1), 58. https://doi.org/10.1186/s12882-022-02694-x
Singh, D., Biju, B., Kumar, L., Arya, S., & Singh, A. (2023). Assessing the Impact of Health Education on Health Behavior Change. Journal of Chemical Health Risks, 13(06), 2380-2387. https://jchr.org/index.php/JCHR/article/view/2160
Suh, K. H. (2021). Verification of a theory of planned behavior model of medication adherence in Korean adults: Focused on moderating effects of optimistic or present bias. BMC Public Health, 21(1), 1391. https://doi.org/10.1186/s12889-021-11460-x
Szucs, L. E., Andrzejewski, J. D., Robin, L., Telljohann, S., Pitt Barnes, S., & Hunt, P. (2021). The Health Education Teacher Instructional Competency Framework: A Conceptual Guide for Quality Instruction in School Health. Journal of School Health, 91(10), 774-787. https://doi.org/10.1111/josh.13076
World Medical Association. (1964, June). Declaration of Helsinki: Recommendations guiding doctors in clinical research. https://www.wma.net/wp-content/uploads/2016/11/DoH-Jun1964.pdf
Yakupova, E. I., Abramicheva, P. A., Bocharnikov, A. D., Andrianova, N. V., & Plotnikov, E. Y. (2023). Biomarkers of the end-stage renal disease progression: Beyond the GFR. Biochemistry (Moscow), 88(10), 1622–1644. https://doi.org/10.1134/S0006297923100164
Zhang, Z., & Hyland, K. (2022). Fostering student engagement with feedback: An integrated approach. Assessing Writing, 51, 100586. https://doi.org/https://doi.org/10.1016/j.asw.2021.100586
Zhang, Z., Liang, X. T., He, X. W., Zhang, X., Tang, R., Fang, R. D., & and Li, J. Z. (2025). Enhancing treatment adherence in dialysis patients through digital health interventions: A systematic review and meta-analysis of randomized controlled trials. Renal Failure, 47(1), 2482885. https://doi.org/10.1080/0886022X.2025.2482885
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