Interventions to Improve Medication Adherence in Hypertensive Patients: A Bibliometric Analysis
DOI:
https://doi.org/10.31674/mjn.2024.v16isupp1.017Abstract
Background: Hypertension is the leading cause of cardiovascular disease, stroke, kidney disease, and global mortality. Adherence to medication is essential to control blood pressure in patients with hypertension. Therefore, effective interventions to improve medication adherence are essential. Objective: The purpose of this study was to identify interventions to improve hypertension treatment adherence by analysing network visualisation, overlay visualisation, and density visualisation on topics through bibliometric analysis. Methods: The data sources used in this study are based on online searches through dimensions. AI The literature search used stages following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. Articles published between 2022 and 2024. Field of study focuses on health science, health services, public health, nursing, and health systems. Accepted document types are articles. Research topics address interventions to improve hypertension treatment adherence, including digital technology, patient education, health literacy, psychological approaches, family participation, and health worker interventions. Articles were identified using the platform according to the main keywords: hypertension, interventions to improve, and medication adherence. Data were analysed using VOSviewer. Results: To improve hypertension medication adherence, healthcare providers need to improve patients' literacy and knowledge about their disease. The use of technologies such as mHealth, telemedicine, eHealth, text messaging, and WeChat has been shown to be effective in improving medication adherence. In addition, motivation and psychological services can also help improve medication adherence. Education and counselling from pharmacists, nurses, doctors, and community health workers, as well as telephone support, also play an important role. Family participation can further support the improvement of antihypertensive medication adherence. Conclusion: After identifying the clusters, the types of interventions that can improve hypertension treatment adherence are patient education and health literacy, use of technology, psychological approaches, health professional interventions, and family participation.
Keywords:
Bibliometric, Hypertension, Interventions to Improve, Medication AdherenceDownloads
References
Abbas, S. M., Salama, H. M., Nour-Eldein, H., & Ahmed, H. A. S. (2024). Health coaching for hypertension control in primary care patients with uncontrolled hypertension in Egypt. Journal of Family and Community Medicine, 31(1), 16-24. https://doi.org/10.4103/jfcm.jfcm_174_23
Abegaz, T. M., Shehab, A., Gebreyohannes, E. A., Bhagavathula, A. S., & Elnour, A. A. (2017). Nonadherence to antihypertensive drugs: A systematic review and meta-analysis. Medicine, 96(4). https://doi.org/10.1097/MD.0000000000005641
Al Ali, N. M., & Telfah, R. K. (2023). The effect of health literacy in explaining medication adherence among patients with hypertension: A cross‐sectional study of Syrian refugees in Jordan. International Journal of Nursing Practice, 29(3). https://doi.org/10.1111/ijn.13136
Avegno, K. S., Roberson, K. B., Onsomu, E. O., Edwards, M. F., Dean, E. L., & Bertoni, A. G. (2023). Evaluating a telephone and home blood pressure monitoring intervention to improve blood pressure control and self-care behaviors in adults with low-socioeconomic status. International Journal of Environmental Research and Public Health, 20(7). https://doi.org/10.3390/ijerph20075287
Babazadeh, T., Ranjbaran, S., Pourrazavi, S., Latifi, A., & Maleki Chollou, K. (2024). Impact of health literacy and illness perception on medication adherence among older adults with hypertension in Iran: A cross-sectional study. Frontiers in Public Health, 12. https://doi.org/10.3389/fpubh.2024.1347180
Bernardes, M. L., Rosendo-Silva, B., Rosendo, I., & Monteiro-Soares, M. (2023). Web-based interventions to improve blood pressure control in patients with hypertension: a protocol for a systematic review. BMJ Open, 13(8). https://doi.org/10.1136/bmjopen-2022-067610
Boima, V., Doku, A., Agyekum, F., Tuglo, L. S., & Agyemang, C. (2024). Effectiveness of digital health interventions on blood pressure control, lifestyle behaviours and adherence to medication in patients with hypertension in low-income and middle-income countries: a systematic review and meta-analysis of randomised controlled trials. EClinicalMedicine, 69https://doi.org/10.1016/j.eclinm.2024.102432
Brewer, L. C., Jones, C., Slusser, J. P., Pasha, M., Lalika, M., Chacon, M., Takawira, P., Shanedling, S., Erickson, P., Woods, C., Krogman, A., Ferdinand, D., Underwood, P., Cooper, L. A., Patten, C. A., & Hayes, S. N. (2023). mHealth Intervention for Promoting Hypertension Self- management Among African American Patients Receiving Care at a Community Health Center: Formative Evaluation of the FAITH! Hypertension App. JMIR Formative Research, 7. https://doi.org/10.2196/45061
Bukar, U. A., Sayeed, M. S., Razak, S. F. A., Yogarayan, S., Amodu, O. A., & Mahmood, R. A. R. (2023). A method for analyzing text using VOSviewer. MethodsX, 11. https://doi.org/10.1016/j.mex.2023.102339
Bulto, L. N., Roseleur, J., Noonan, S., Pinero de Plaza, M. A., Champion, S., Dafny, H. A., ... & Hendriks, J. M. (2024). Effectiveness of nurse-led interventions versus usual care to manage hypertension and lifestyle behaviour: A systematic review and meta-analysis. European Journal of Cardiovascular Nursing, 23(1), 21-32. https://doi.org/10.1093/eurjcn/zvad040
Chellappandi, P., & Vijayakumar, C. S. (2018). Bibliometrics, Scientometrics, Webometrics/Cybermetrics, Informetrics and Altmetrics--An Emerging Field in Library and Information Science Research. Shanlax International Journal of Education, 7(1), 5-8. https://doi.org/http/doi.org/10.5281/zenodo.2529398
Desta, R., Blumrosen, C., Laferriere, H. E., Saluja, A., Bruce, M. A., Elasy, T. A., ... & Umeukeje, E. M. (2022). Interventions incorporating therapeutic alliance to improve medication adherence in black patients with diabetes, hypertension and kidney disease: A systematic review. Patient Preference and Adherence, 16, 3095-3110. https://doi.org/10.2147/ppa.s371162
Dietrich, F., Zeller, A., Hersberger, K. E., & Arnet, I. (2024). Adherence Monitoring Package (AMoPac) in patients suspected of non-response to antihypertensive treatment: Perceived usefulness by general practitioners. BMJ Open Quality, 13(1). https://doi.org/10.1136/bmjoq-2023- 002451
Donovan, G., Hall, N., Ling, J., Smith, F., & Wilkes, S. (2022). Influencing medication taking behaviors using automated two‐way digital communication: A narrative synthesis systematic review informed by the Behavior Change Wheel. British Journal of Health Psychology, 27(3), 861- 890. https://doi.org/10.1111/bjhp.12580
Etminani, K., Göransson, C., Galozy, A., Pejner, M. N., & Nowaczyk, S. (2021). Improving medication adherence through adaptive digital interventions (imeda) in patients with hypertension: Protocol for an interrupted time series study. JMIR Research Protocols, 10(5). https://doi.org/10.2196/24494
Fallatah, M. S., Alghamdi, G. S., Alzahrani, A. A., Sadagah, M. M., & Alkharji, T. M. (2023). Insights Into Medication Adherence Among Patients with Chronic Diseases in Jeddah, Saudi Arabia: A Cross-Sectional Study. Cureus, 15(4). https://doi.org/10.7759/cureus.37592
Velázquez Fuentes, M. N., Shah, P., & Hale, G. M. (2022). Improving medication adherence in patients with hypertension through pharmacist-led telehealth services. Journal of Telemedicine and Telecare, 28(8), 613-617. https://doi.org/10.1177/1357633x221076719
Gardezi, S. K. M., Aitken, W. W., & Jilani, M. H. (2023). The Impact of Non-Adherence to Antihypertensive Drug Therapy. Healthcare, 11(22). https://doi.org/10.3390/healthcare11222979
Guo, A., Jin, H., Mao, J., Zhu, W., Zhou, Y., Ge, X., & Yu, D. (2023). Impact of health literacy and social support on medication adherence in patients with hypertension: a cross-sectional community-based study. BMC Cardiovascular Disorders, 23(1), 93. https://doi.org/10.1186/s12872-023-03117-x
Huang, X., Xu, N., Wang, Y., Sun, Y., & Guo, A. (2023). The effects of motivational interviewing on hypertension management: a systematic review and meta-analysis. Patient Education and Counseling, 112. https://doi.org/10.1016/j.pec.2023.107760
Kappes, M., Espinoza, P., Jara, V., & Hall, A. (2023). Nurse-led telehealth intervention effectiveness on reducing hypertension: a systematic review. BMC Nursing, 22(1). https://doi.org/10.1186/s12912-022-01170-z
Karami, M., Ashtarian, H., Rajati, M., Hamzeh, B., & Rajati, F. (2023). The effect of health literacy intervention on adherence to medication of uncontrolled hypertensive patients using the M-health. BMC Medical Informatics and Decision Making, 23(1). https://doi.org/10.1186/s12911-023- 02393-z
Kassavou, A., Mirzaei, V., Brimicombe, J., Edwards, S., Massou, E., Prevost, A. T., ... & Sutton, S. (2020). A highly tailored text and voice messaging intervention to improve medication adherence in patients with either or both hypertension and type 2 diabetes in a UK primary care setting: feasibility randomized controlled trial of clinical effectiveness. Journal of Medical Internet Research, 22(5). https://doi.org/10.2196/16629
Katz, M. E., Mszar, R., Grimshaw, A. A., Gunderson, C. G., Onuma, O. K., Lu, Y., & Spatz, E. S. (2024). Digital health interventions for hypertension management in US populations experiencing health disparities: A systematic review and meta-analysis. JAMA Network Open, 7(2), 1-17. https://doi.org/10.1001/jamanetworkopen.2023.56070
Kengne, A. P., Brière, J. B., Gudiña, I. A., Jiang, X., Kodjamanova, P., Bennetts, L., & Khan, Z. M. (2024). The impact of non-pharmacological interventions on adherence to medication and persistence in dyslipidaemia and hypertension: A systematic review. Expert Review of Pharmacoeconomics & Outcomes Research, 24(7), 807–816. https://doi.org/10.1080/14737167.2024.2319598
Kes, D., & Polat, U. (2022). The effect of nurse‐led telephone support on adherence to blood pressure control and drug treatment in individuals with primary hypertension: A randomized controlled study. International Journal of Nursing Practice, 28(3). https://doi.org/10.1111/ijn.12995
Kisigo, G. A., Mcharo, O. C., Robert, J. L., Peck, R. N., Sundararajan, R., & Okello, E. S. (2022). Understanding barriers and facilitators to clinic attendance and medication adherence among adults with hypertensive urgency in Tanzania. PLoS Global Public Health, 2(8). https://doi.org/10.1371/journal.pgph.0000919
Koya, S. N. M. M. (2024). Cardiovascular Medication Saving Activity during Dispensing Process at Specialist Clinic Pharmacy in Malaysia. Malaysian Journal of Medical Research (MJMR), 8(4), 9-19. https://doi.org/10.31674/mjmr.2024.v08i04.002
Kwakye, A. O., Kretchy, I. A., Peprah, P., & Mensah, K. B. (2024). Factors influencing medication adherence in co-morbid hypertension and diabetes patients: A scoping review. Exploratory Research in Clinical and Social Pharmacy, 13. https://doi.org/10.1016/j.rcsop.2024.100426
Li, W. W., & Toh, P. (2023). WeChat-based intervention for Chinese immigrants with hypertension: development and evaluation study. Asian/Pacific Island Nursing Journal, 7(1). https://doi.org/10.2196/45769
Li, X., Hu, J., Yao, Y., Zuo, C., Wang, Z., Li, X., & Lv, Q. (2022). Evaluation of pharmacist-led telemedicine medication management for hypertension established patients during COVID-19 pandemic: A pilot study. Frontiers in Public Health, 10. https://doi.org/10.3389/fpubh.2022.1091484
Lobo, E. H., Karmakar, C., Abdelrazek, M., Abawajy, J., Chow, C. K., Zhang, Y., ... & Islam, S. M. S. (2023). Design and development of a smartphone app for hypertension management : An intervention mapping approach. Frontiers in Public Health, 11. https://doi.org/10.3389/fpubh.2023.1092755
Martínez-Ibáñez, P., Marco-Moreno, I., Peiró, S., Martínez-Ibáñez, L., Barreira-Franch, I., Bellot- Pujalte, L., ... & Sanfélix-Genovés, J. (2023). Home blood pressure self-monitoring plus self- titration of antihypertensive medication for poorly controlled hypertension in primary care: The ADAMPA randomized clinical trial. Journal of General Internal Medicine, 38(1), 81-89. https://doi.org/10.1007/s11606-022-07791-z
Mehta, S. J., Volpp, K. G., Troxel, A. B., Teel, J., Reitz, C. R., Purcell, A., ... & Asch, D. A. (2024). Remote Blood Pressure Monitoring with Social Support for Patients with Hypertension: A Randomized Clinical Trial. JAMA Network Open, 7(6). https://doi.org/10.1001/jamanetworkopen.2024.13515
Mozu, I. E., Marfo, A. F. A., Marfo, J. S., Adomako, N. O., Ayisi-Boateng, N. K., Boachie-Ansah, P., ... & Owusu-Daaku, F. T. (2023). Utilization of telepharmacy in the management of hypertension. Exploratory Research in Clinical and Social Pharmacy, 12. https://doi.org/10.1016/j.rcsop.2023.100381
Murugesu, G. V., Khalid, S. A., & Shareef, H. (2022). Bibliometric analysis on microbial fuel cell research trend in electronic engineering perspective. ASEANA Science and Education Journal, 2(2), 1-10. https://doi.org/10.53797/aseana.v2i2.1.2022
Nelson, L. A., Spieker, A. J., Kripalani, S., Rothman, R. L., Roumie, C. L., Coco, J., ... & McNaughton, C. D. (2022). User preferences for and engagement with text messages to support antihypertensive medication adherence: findings from a pilot study evaluating an emergency department-based behavioral intervention. Patient Education and Counseling, 105(6), 1606-1613. https://doi.org/10.1016/j.pec.2021.10.011
Ni, Z., Wu, B., Yang, Q., Yan, L. L., Liu, C., & Shaw, R. J. (2022). An mHealth intervention to improve medication adherence and health outcomes among patients with coronary heart disease: Randomized controlled trial. Journal of Medical Internet Research, 24(3). https://doi.org/10.2196/27202
Noreen, N., Bashir, F., Khan, A. W., Safi, M. M., Lashari, W. A., & Hering, D. (2023). Determinants of Adherence to Antihypertension Medications Among Patients at a Tertiary Care Hospital in Islamabad, Pakistan, 2019. Preventing Chronic Disease, 20, E42. 1–14. https://doi.org/10.5888/PCD20.220231
Onakomaiya, D., Cooper, C., Barber, A., Roberts, T., Gyamfi, J., Zanowiak, J., ... & Schoenthaler, A. (2022). Strategies to improve medication adherence and blood pressure among racial/ethnic minority populations: A scoping review of the literature from 2017 to 2021. Current Hypertension Reports, 24(12), 639-654. https://doi.org/10.1007/s11906-022-01224-2
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., ... & Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372(71). https://doi.org/10.1136/bmj.n71
Pallangyo, P., Komba, M., Mkojera, Z. S., Kisenge, P. R., Bhalia, S., Mayala, H., Kifai, E., Richard M. K., Khanbhai, K., Wibonela, S., Millinga, J., Yeyeye, R., Njau, N. F., Odemary, T. K., & Janabi, M. (2022). Medication adherence and blood pressure control among hypertensive outpatients attending a tertiary cardiovascular hospital in Tanzania: A cross-sectional study. Integrated Blood Pressure Control, 15, 97–112. https://doi.org/10.2147/IBPC.S374674
Pan, Q., Zhang, C., Yao, L., Mai, C., Zhang, J., Zhang, Z., & Hu, J. (2023). Factors Influencing Medication Adherence in Elderly Patients with Hypertension: A Single Center Study in Western China. Patient Preference and Adherence, 17, 1679–1688. https://doi.org/10.2147/ppa.s418246
Persell, S. D., Peprah, Y. A., Lipiszko, D., Lee, J. Y., Li, J. J., Ciolino, J. D., ... & Sato, H. (2020). Effect of home blood pressure monitoring via a smartphone hypertension coaching application or tracking application on adults with uncontrolled hypertension: A randomized clinical trial. JAMA Network Open, 3(3), e200255-e200255. https://doi.org/10.1001/jamanetworkopen.2020.0255
Poorcheraghi, H., Negarandeh, R., Pashaeypoor, S., & Jorian, J. (2023). Effect of using a mobile drug management application on medication adherence and hospital readmission among elderly patients with polypharmacy: a randomized controlled trial. BMC Health Services Research, 23(1), 1192. https://doi.org/10.1186/s12913-023-10177-4
Sarkar, A., Nwokocha, C., Nash, S. G., & Grigoryan, L. (2024). Empowering low-income patients with home blood pressure monitors to improve hypertension control. The Journal of the American Board of Family Medicine, 37(2), 187-195. https://doi.org/10.3122/jabfm.2023.230357r1
Shen, B., Guan, T., Du, X., Pei, C., Zhao, J., & Liu, Y. (2022). Medication adherence and perceived social support of hypertensive patients in China: a community-based survey study. Patient Preference and Adherence, 16, 1257–1268. https://doi.org/10.2147/PPA.S363148
Shen, Z., Ding, S., Shi, S., & Zhong, Z. (2022). Association between social support and medication literacy in older adults with hypertension. Frontiers in Public Health, 10. https://doi.org/10.3389/fpubh.2022.987526
Simon, E., Edwards, A. M., Sajatovic, M., Jain, N., Montoya, J. L., & Levin, J. B. (2022). Systematic Literature Review of Text Messaging Medication Adherence Promotion Interventions in People with Serious Mental Illness. Psychiatric Services (Washington, DC), 73(10). https://doi.org/10.1176/appi.ps.202100634
Siopis, G., Moschonis, G., Eweka, E., Jung, J., Kwasnicka, D., Asare, B. Y. A., ... & Bruka, L. (2023). Effectiveness, reach, uptake, and feasibility of digital health interventions for adults with hypertension: A systematic review and meta-analysis of randomised controlled trials. The Lancet Digital Health, 5(3). https://doi.org/10.1016/s2589-7500(23)00002-x
Soubra, L., & Elba, G. (2023). Pharmacist role in hypertension management in the community setting: questionnaire development, validation, and application. Patient Preference and Adherence, 17, 351-367. https://doi.org/10.2147/PPA.S394855
Svarstad, B. L., Brown, R. L., & Shireman, T. I. (2022). A successful intervention to improve medication adherence in Black patients with hypertension: Mediation analysis of 28-site TEAM trial. Journal of the American Pharmacists Association, 62(3), 800-808. https://doi.org/10.1016/j.japh.2022.01.002
Syros, A., Perez, O. F., Luxenburg, D., Cohen, J. L., Swonger, R., & Huntley, S. (2022). The most influential studies concerning revision shoulder arthroplasty research. Journal of Orthopaedics, 34, 349-356. https://doi.org/10.1016/j.jor.2022.09.019
Tjahjono, B., Arfian, M. H., Hastuti, L., Ichwani, A., & Marini, D. (2024). Pelatihan Penggunaan Aplikasi Open-Source Dimensions AI Untuk Eksplorasi Data Literasi Reference Manager. IKRA- ITH ABDIMAS, 8(2), 308–315. https://doi.org/10.37817/ikra-ithabdimas.v8i2
Tjandrarini, D. H., Kristanti, D., Wurisastuti, T., Hidayangsih, P. S., Tuminah, S., Paramita, A., ... & Titaley, C. R. (2024). Pandemic Pressure: Changes in Hypertensive Management Adherence in Indonesia. Asian Nursing Research, 18(2), 134-140. https://doi.org/10.1016/j.anr.2024.04.005
World Health Organization. (2023). Global report on hypertension: The race against a silent killer. Geneva: World Health Organization. Retrieved from: https://www.who.int/publications/i/item/9789240081062 . Accessed on 10th January, 2024.
Yilmaz, E., Uzuner, A., Bajgora, M., Dogan, B., Altikardes, Z. A., Geris, B. K., & Akdeniz, E. (2022). Effect of eTansiyon smartphone application on hypertension control. Primary Health Care Research & Development, 23. https://doi.org/10.1017/s146342362100058x
Yuting, Z., Xiaodong, T., & Qun, W. (2023). Effectiveness of a mHealth intervention on hypertension control in a low-resource rural setting: A randomized clinical trial. Frontiers in Public Health, 11. https://doi.org/10.3389/fpubh.2023.1049396
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