Characteristics and Status of Treatment for Multi-Drug-Resistant Tuberculosis (MDRTB) Patients in a TB-DOTS Centre in the Province of Jolo, Sulu, Philippines
DOI:
https://doi.org/10.31674/mjn.2024.v16i01.006Abstract
Background: The study focuses on the characteristics and status of treatment for multi-drug-resistant tuberculosis (MDRTB) at the TB-DOTS Centres of Jolo Sulu from 2018 to 2019. Objective: The study's primary goal is to describe and investigate MDRTB treatment characteristics and status, as well as identify factors that influence treatment. Methods: A mixed-methods research design through an explanatory sequential approach was used. The quantitative approach employed data mining of existing and available data records of MDR-TB clients at respective health centres at Jolo and Sulu and tools assessing factors influencing treatment. The qualitative approach was done through interviews with the MDR-TB clients, and total remuneration and purposive sampling were applied in selecting participants. The data gathered were presented using frequency and percentage distribution and processed using SPSS v.21, and themes and subthemes were extracted and analyzed using In-Vivo qualitative software. Results: MDR-TB clients were mostly mid-adults and heads of families, with a treatment history focusing more on pulmonary relapse (the first line of defense) and poor treatment outcomes. The factors that influenced treatment were financial constraints, lack of knowledge, distance, transportation, and work. Themes derived include contagious yet treatable disease, challenging family socio-economic status, role justification, and treatment centres as havens. Conclusion: The study highlights the need for a comprehensive assessment of the status of the health condition of TB clients and patients enrolled at the TB-DOTS centre of Jolo Sulu. Nursing plays a vital role in managing and treating TB in these areas. The findings suggest that financial constraints, lack of knowledge, and access to treatment are significant barriers to MDRTB treatment. The study emphasizes the need for interventions to improve TB treatment outcomes and reduce the burden of MDRTB in the community.
Keywords:
Multi-Drug Resistant, Philippines, Tuberculosis, Treatment, TB-DOTSDownloads
References
Adisa, R., Ayandokun, T. T., & Ige, O. M. (2021). Knowledge about tuberculosis, treatment adherence and outcome among ambulatory patients with drug-sensitive tuberculosis in two directly-observed treatment centres in Southwest Nigeria. BMC Public Health, 21(1), 677. https://doi.org/10.1186/s12889-021-10698-9
Al-Noumani, H., Al Omari, O., & Al-Naamani, Z. (2023). Role of health literacy, social support, patient-physician relationship, and health-related quality of life in predicting medication adherence in cardiovascular diseases in Oman. Patient Preference and Adherence, 643-652. https://doi.org/10.2147/ppa.s401666
Alene, K. A., Viney, K., McBryde, E. S., Gray, D. J., Melku, M., & Clements, A. C. A. (2019). Risk factors for multidrug-resistant tuberculosis in northwest Ethiopia: A case–control study. Transboundary and Emerging Diseases, 66(4), 1611-1618. https://doi.org/https://doi.org/10.1111/tbed.13188
Allué-Guardia, A., García, J. I., & Torrelles, J. B. (2021). Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment. Front Microbiol, 12, 612675. https://doi.org/10.3389/fmicb.2021.612675
Alsulami, S. H., Yasin, F., Afzal, Z., & Shahid, M. (2024). Efficient Solutions with the LRPS Method for Non-Linear Fractional Order Tuberculosis Models. Trends in Sciences, 21(5), 7379-7379. https://doi.org/10.48048/tis.2024.7379
Bernardo, M. N. G., Alberto, I. R. I., Alberto, N. R. I., Eala, M. A. B., & Roa, C. C. (2022). The way forward for drug-resistant tuberculosis in the Philippines. The Lancet Infectious Diseases, 22(6), 760.https://doi.org/10.1016/s1473-3099(22)00285-7
Biset, S., Teferi, M., Alamirew, H., Birhanu, B., Dessie, A., Aschale, A., ... & Adane, G. (2024). Trends of Mycobacterium tuberculosis and Rifampicin resistance in Northwest Ethiopia: Xpert® MTB/RIF assay results from 2015 to 2021. BMC Infectious Diseases, 24(1), 238. https://doi.org/10.1186/s12879-024-09135-0
Bruno, J. A. (1973). The Social World of the Tausug: A Study in Philippine Culture and Education. Centro Escolar University, Research and Development Centre. Philippines. https://catalogue.nla.gov.au/catalog/2990349
Dean, A. S., Auguet, O. T., Glaziou, P., Zignol, M., Ismail, N., Kasaeva, T., & Floyd, K. (2022). 25 years of surveillance of drug-resistant tuberculosis: achievements, challenges, and way forward. The Lancet Infectious Diseases, 22(7), e191-e196. https://doi.org/10.1016/s1473-3099(21)00808-2
Dhestina, W., Santoso, P., & Sahiratmadja, E. (2022). Proportion of Extrapulmonary MDR-TB Confirmed by GeneXpert® in Dr. Hasan Sadikin General Hospital, West Java, Indonesia Year 2012–2021. Indonesian Journal of Tropical and Infectious Disease. https://doi.org/10.20473/ijtid.v10i2.33768
Gebreweld, F. H., Kifle, M. M., Gebremicheal, F. E., Simel, L. L., Gezae, M. M., Ghebreyesus, S. S., ... & Wahd, N. G. (2018). Factors influencing adherence to tuberculosis treatment in Asmara, Eritrea: a qualitative study. Journal of Health, Population and Nutrition, 37, 1-9.https://doi.org/10.1186/s41043-017-0132-y
Ivankova, N. V., Creswell, J. W., & Stick, S. L. (2006). Using mixed-methods sequential explanatory design: From theory to practice. Field Methods, 18(1), 3-20.https://doi.org/10.1177/1525822x05282260
Kak, N., Chakraborty, K., Sadaphal, S., AlMossawi, H. J., Calnan, M., & Vikarunnessa, B. (2020). Strategic priorities for TB control in Bangladesh, Indonesia, and the Philippines–comparative analysis of national TB prevalence surveys. BMC Public Health, 20, 1https://doi.org/10.1186/s12889-020-08675-9
Kimani, E., Muhula, S., Kiptai, T., Orwa, J., Odero, T., & Gachuno, O. (2021). Factors influencing TB treatment interruption and treatment outcomes among patients in Kiambu County, 2016-2019. PloS One, 16(4), e0248820.https://doi.org/10.1371/journal.pone.0248820
Labrague, L. J. (2024). Umbrella Review: Stress Levels, Sources of Stress, and Coping Mechanisms among Student Nurses. Nursing Reports, 14(1), 362-375. https://doi.org/10.3390/nursrep14010028
Lansang, M. A. D., Alejandria, M. M., Law, I., Juban, N. R., Amarillo, M. L. E., Sison, O. T., ... & Philippine NTPS 2016 Group. (2021). High TB burden and low notification rates in the Philippines: The 2016 national TB prevalence survey. PloS One, 16(6), e0252240. https://doi.org/10.1371/journal.pone.0252240
Macapagal, M. E. J., Montiel, C. J., & Canuday, J. J. P. (2018). The unifying and divisive effects of social identities: Religious and ethnopolitical identities among Mindanao Muslims in the Philippines. Journal of Pacific Rim Psychology, 12, e28. https://doi.org/10.1017/prp.2018.16
Maifitrianti, M., Wiyati, T., & Hasanah, N. Relationship between Patients’ Knowledge and Medication Adherence of Tuberculosis at Islamic Hospital Pondok Kopi Jakarta. JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice), 14(1), 69-75. [Maifitrianti, M., Wiyati, T., & Hasanah, N. Relationship between Patients' Knowledge and Medication Adherence of Tuberculosis at Islamic Hospital Pondok Kopi Jakarta. JOURNAL of Management and Pharmacy Practice, 14(1), 69-75.] https://doi.org/10.22146/jmpf.86864
Mase, S. R., & Chorba, T. (2019). Treatment of Drug-Resistant Tuberculosis. Clinics in Chest Medicine, 40(4), 775-795. https://doi.org/10.1016/j.ccm.2019.08.002
Mukattil, N. ., & Pangandaman, H. (2024). Barriers and Strategies in the Implementation of Virtual Learning Modalities Amid COVID-19 among Students in Nursing Schools at Sulu Province, Philippines. Critical Medical and Surgical Nursing Journal (CMSNJ), 13(1), 20–25. https://doi.org/10.20473/cmsnj.v13i1.51366
Mutembo, S., Mutanga, J. N., Musokotwane, K., Kanene, C., Dobbin, K., Yao, X., ... & Whalen, C. C. (2019). Urban-rural disparities in treatment outcomes among recurrent TB cases in Southern Province, Zambia. BMC Infectious Diseases, 19, 1-8.https://doi.org/10.1186/s12879-019-4709-5
PSA. (2021). Philippine Statistics Authority: Official Poverty Statistics of the Philippines: First Semester 2021 https://psa.gov.ph/poverty-press-releases. Accessed on 10th May, 2022.
Qazi, N., Jamali, S. N., Aftab, A., Ahmed, I., Memon, S., & Kumar, G. (2022). Multi Drug Resistance: A Continuous Challenge by a Century Old Mycobacterium Tuberculosis. Journal of Pharmaceutical Research International, 34(45A), 53-57.https://doi.org/10.9734/jpri/2022/v34i45a36354
Sari, N. P., Juniarti, N., & Yani, D. I. (2020). Development of Guidelines for Observer Tuberculosis Patients In Tasikmalaya City, Indonesia. Malaysian Journal of Medical Research (MJMR), 4(3), 15-25. https://doi.org/10.31674/mjmr.2020.v04i03.004
Subih, M. M., Abu Saleh, F., & Malak, M. Z. (2023). Medication adherence among patients with cardiovascular diseases: a cross-sectional study. Journal of Research in Nursing, 28(4), 272-282.https://doi.org/10.1177/17449871231175737
Octaviani, P., Ikawati, Z., Yasin, N. M., Kristina, S. A., & Kusuma, I. Y. (2024). Interventions to Improve Adherence to Medication on Multidrug-Resistant Tuberculosis Patients: A Scoping Review. The Medical Journal of Malaysia, 79(2), 212-221. https://www.e-mjm.org/2024/v79n2/adherence-intervention.pdf
Prabal, P. A., & Maiti, S. (2018). Assessing the utility of Genexpert as a diagnostic tool in the detection of Tuberculosis in a neurological tertiary care setup. International Journal of Advancement in Life Sciences Research, 22-29.https://doi.org/10.31632/ijalsr.2018v01i03.004
Tupasi, T., Garfin, A. M. C. G., Mangan, J. M., Orillaza-Chi, R., Naval, L. C., Balane, G. I., ... & Kurbatova, E. V. (2017). Multidrug-resistant tuberculosis patients' views of interventions to reduce treatment loss to follow-up. The International Journal of Tuberculosis and Lung Disease, 21(1), 23-31. https://doi.org/10.5588/ijtld.16.0433
Tupasi, T. E., Garfin, A. M. C. G., Kurbatova, E. V., Mangan, J. M., Orillaza-Chi, R., Naval, L. C., ... & Sarol Jr, J. N. (2016). Factors associated with loss to follow-up during treatment for multidrug-resistant tuberculosis, the Philippines, 2012–2014. Emerging infectious diseases, 22(3), 491.https://doi.org/10.3201/eid2203.151788
Vaismoradi, M., Turunen, H., & Bondas, T. (2013). Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. Nursing & Health Sciences, 15(3), 398-405. https://doi.org/10.1111/nhs.12048
Weiler, G. (2019). It’s time to end TB in the Philippines. World Health Organization, Western Pacific Philippines. https://www.who.int/philippines/news/commentaries/detail/it-s-time-to-end-tb-in-the-philippines . Accessed 11th October, 2022.
World Health Organization. (2020). Ensuring ethical standards and procedures for research with human beings. Published 2020. https://www.who.int/philippines/news/commentaries/detail/it-s-time-to-end-tb-in-the-philippines. Accessed on 17th June, 2022
Wright, D. F. B., Sinnappah, K. A., & Hughes, D. (2023). Medication Adherence Research Comes of Age. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.15722
Yabes, C. (2021). Creating sulu: In search of policy coalitions in the conflict-ridden island. Southeast Asian Studies, 10(2), 295-312.https://doi.org/https://doi.org/10.20495/seas.10.2_295
Wang, L., Dong, H. M., Zhao, X., & Yang, Z. C. (2023). Design, synthesis, and molecular docking studies of chroman-4-one linked thiosemicarbazide derivatives as inhibitors of KatG and anti-Mycobacterium tuberculosis agents. Heterocycles: an International Journal for Reviews and Communications in Heterocyclic Chemistry, 106(6), 1047-1063.https://doi.org/10.3987/com-23-14851
Zaporojan, N., Negrean, R. A., Hodișan, R., Zaporojan, C., Csep, A., & Zaha, D. C. (2024). Evolution of laboratory diagnosis of tuberculosis. Clinics and Practice, 14(2), 388-416. https://doi.org/10.3390/clinpract14020030
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