THE EFFECT AND ESTIMATION OF “RALOXIFENE (IN ADDITION TO CALCIUM AND VITAMIN D3 SUPPLEMENTATION) ON AEDS”-INDUCED CHANGES IN BONE MINERAL DENSITY AND BONE TURNOVER" MARKERS.

Authors

  • Assoc.Prof.Mohammad Gousuddin Lincoln University College
  • Wang Xiaoli Faculty of Pharmacy, Lincoln University College, No.2, Jalan Stadium, SS7/15, Kelana Jaya, 47301 Petaling Jaya, Selangor, Darul Ehsan, Malaysia
  • Sun Chao Faculty of Pharmacy, Lincoln University College, No.2, Jalan Stadium, SS7/15, Kelana Jaya, 47301 Petaling Jaya, Selangor, Darul Ehsan, Malaysia

Abstract

Antiepileptic medications are frequently required for the rest of a person's life if they suffer from epilepsy, a common neurological illness (AEDs). Recent decades have shown that long-term use of AEDs can lead to bone loss and a greater risk of fracture. Long-term use of AEDs has been shown to decrease BMD, increase the risk of fracture, and even cause overt osteomalacia, according to new clinical data AED-related bone fragility may be caused by a variety of mechanisms, but the most common AEDs that have been linked to bone metabolism disorders are CYP 450 monoxygenase system inducers (phenytoin, carbamazepine, and phenobarbitone) Thus, the present study was designed. the effect of “raloxifene (in addition to calcium and vitamin D3 supplementation) on AEDs”-induced changes in bone mineral density and bone turnover" markers. And estimation of hydroxyproline, calcium and Creatinine

Keywords:

Epilepsy, AED: Anti-epileptic drugs therapy CYP

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Published

24-07-2025

How to Cite

Assoc.Prof.Mohammad Gousuddin, Wang Xiaoli, & Sun Chao. (2025). THE EFFECT AND ESTIMATION OF “RALOXIFENE (IN ADDITION TO CALCIUM AND VITAMIN D3 SUPPLEMENTATION) ON AEDS”-INDUCED CHANGES IN BONE MINERAL DENSITY AND BONE TURNOVER" MARKERS. International Journal of Food, Drug and Cosmetics (IJFDC), 1(1), 57-74. Retrieved from https://ejournal.lucp.net/index.php/ijfdc/article/view/3162

Issue

Vol. 1 No. 1 (2025): International Journal of Food, Drug and Cosmetics

Section

Articles