FORMULATION AND INVITRO EVALUATION OF TERBUTALINE SULPHATE TRANSDERMAL PATCHES

Abstract

ABSTRACT:

In the present work, attempts were made to prepare and evaluate “Terbutaline sulphate transdermal patches”. It acts as controlled and sustained release bronchodilator. Technique used to prepare these polymeric patches is solvent evaporating technique, used various ratios of ethyl cellulose, HPMC, glycol, terbutaline sulphate etc,. From T1-T5 combination with active ingredient, eudragid RL and from T6-T10 ethyl cellulose were used. Require quantity of polymer measure n taken and allow swelling for hours in solvent (which is combination of ethanol and dichloromethane equally) included plasticizer as well. Mixing of polymeric and drug solution followed by spreading on petriplate of surface area about 6.9 cm² kept for drying followed by vacuum drying for few hours. From the area 6.9 cm² cut the patches from complete sheet. About 10 patches of terbutaline sulphate were formed from single sheet. All formulations contain different ratios of ingredients. All typical bands occur due to polymer which shows the report as ‘there is no interaction between polymer and drug’. Bands observed through IR spectrolysis.

The drug release rate was increased with increase in polymer concentration. The patch which contains ethyl cellulose & HPMC E15 gives better release than patches with HPMC E15 & Eudragit RL 100. The drug release kinetics of optimized formulations followed the zero (0) order kinetics and the release mechanism were found to be non-flicking controlled rate mechanism. The research work shows a rational guideline to formulate a controlled release transdermal drug delivery system T9 for efficient therapy.