Exploring The Efficacy of Homeopathic Treatment in Immunologic Disorders: A Case Series Analysis

Goay Lay Nee and Nurul Sofiyah bt Md Shater

School of Pharmacy, Lincoln University College, Wisma Lincoln, No. 12-18, Jalan SS 6/12, 47301 Petaling Jaya, Selangor Darul Ehsan, Malaysia

*Corresponding Author’s Email: laneyluc2020@gmail.com

Abstract

Homeopathy is increasingly acknowledged as a complementary approach for managing autoimmune disorders, although empirical validation remains limited. This retrospective case series evaluates its efficacy in rheumatoid arthritis (RA), dermatitis, Graves’ disease, and mixed connective tissue disease (MCTD). While Traditional and Complementary Medicine (T&CM) is gaining acceptance in Malaysia, scientific studies on its role in autoimmune disease management are scarce. Treatment outcomes were assessed using qualitative and quantitative measures, including clinical symptoms and laboratory markers such as RA factor and Antinuclear Antigen (ANA) levels. Five cases demonstrated notable symptom relief, immune modulation, and improved well-being. RA patients showed reduced joint pain and enhanced mobility, MCTD cases achieved ANA normalization and skin recovery, and a Graves’ disease patient experienced decreased thyroid antibodies, improved eye health, and greater emotional stability. Treatment durations ranged from 24 to 60 months, with chronic cases requiring longer therapy. Common patterns included holistic symptom resolution and enhanced quality of life. However, challenges to empirical validation include small sample size, absence of control groups, and reliance on subjective measures. The lack of placebo-controlled trials limits the ability to attribute improvements solely to homeopathy, while patient adherence and external factors—such as concurrent medical treatments and lifestyle changes—further complicate assessment. Future research should prioritize large-scale randomized controlled trials, incorporate objective biomarkers, and foster interdisciplinary collaboration between homeopaths and conventional practitioners. These findings highlight homeopathy’s potential as a holistic, patient-centered approach in autoimmune disease management, with further rigorous studies needed to establish long-term efficacy and support integration into mainstream healthcare.

Keywords: Autoimmune Disorders; Complementary Medicine; Homeopathy; Immunomodulation; Integrative Healthcare

Introduction Background

Autoimmune diseases are chronic conditions caused by immune system dysfunction, where the body mistakenly attacks its own tissues, leading to inflammation, tissue damage, and organ impairment. Common examples include rheumatoid arthritis (RA), mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE), and Graves’ disease. Despite affecting different systems, these conditions share key features such as autoantibodies, cytokine imbalances, and persistent inflammation.

Conventional treatments typically involve immunosuppressants, corticosteroids, NSAIDs, and DMARDs. While these can reduce symptoms and inflammation, they often come with significant side effects, including digestive issues, liver strain, and increased infection risk. Furthermore, therapeutic responses vary, and many patients continue to face flare-ups or incomplete symptom relief. As autoimmune diseases are long-term and impact both physical and emotional health, there is growing interest in more individualised, holistic approaches that support overall well-being.

Homeopathy and T&CM in Malaysia

Homeopathy, based on the principle of "like cures like" and using highly diluted natural substances, has gained recognition as a complementary therapy for managing chronic and autoimmune conditions. It provides individualised treatment tailored to each patient's unique symptoms and constitutional traits.

In Malaysia, Traditional and Complementary Medicine (T&CM) is officially integrated into the healthcare system, with regulatory frameworks such as the Traditional and Complementary Medicine Act 2016 (Act 775) supporting its use. Homeopathy, while still modest, has seen growing public acceptance, with Mahmud et al. (2009) reporting a 10% utilisation rate and the Ministry of Health Malaysia (2015) indicating increasing public openness and willingness to invest in homeopathic care.

Despite this growing interest, scientific evidence supporting homeopathy’s effectiveness in treating autoimmune diseases remains limited. Most studies face methodological challenges like small sample sizes and subjective outcome measures. Additionally, homeopathy’s individualised approach complicates standardisation, hindering its integration into conventional evidence-based healthcare models and limiting broader acceptance.

Research Objective and Questions

The primary objective of this study is to explore whether individualised homeopathy, based on classical principles, can:

• Evaluate the efficacy of homeopathic treatments for common immunologic disorders, positioning homeopathy as a viable complementary approach.

• Document and analyse individual case outcomes to identify response patterns, aiming to deepen understanding of its potential applications and limitations in clinical practice.

• Contribute to evidence-based practices in homeopathy, promoting further research and discussion on its integration into conventional healthcare.

  To achieve this, the study is guided by the following research questions:

• Can classical homeopathy provide sustained symptom relief in patients with chronic autoimmune conditions?

• Does individualised homeopathy correlate with improvements in clinical biomarkers (e.g., RA factor, TRAb, ANA)?

• What qualitative changes in emotional, mental, and functional health occur during long-term homeopathic treatment?

• Can improvements be attributed to homeopathy using causality frameworks such as the MONARCH criteria?

• Is individualised homeopathy safe and well-tolerated over multiple years in autoimmune disease patients?

  Methodology Study Design

  This study uses a retrospective case series design to explore the therapeutic outcomes of individualised homeopathic treatment in autoimmune disease patients. It aims to evaluate symptom relief, changes in laboratory markers, and overall well-being over extended treatment periods.

  Selection Criteria

  Patients diagnosed with autoimmune disorders like rheumatoid arthritis (RA), mixed connective tissue disease (MCTD), and Graves’ disease were included in the study.

  Inclusion Criteria:

• Confirmed clinical diagnosis of autoimmune disorders (RA, MCTD, Graves’ Disease)

• Consistent individualised homeopathic treatment for at least 24 months

• Accessible medical documentation, including laboratory results and follow-up notes

• History of conventional treatment (discontinued or ongoing)

• Voluntary consent to follow homeopathic protocols and attend follow-up assessments

  Exclusion Criteria:

• Absence of homeopathic treatment

• Incomplete or inaccessible medical documentation

• Insufficient follow-up data for reliable analysis

  Homeopathic Treatments Administered

  Each case was prescribed individualized homeopathic treatment in accordance with classical principles, including the Law of Similars, the use of a single remedy, and the minimum dose approach. The treatment process involved:

• Comprehensive Case Analysis: Initial consultations involved reviewing the patient’s physical complaints, emotional states, medical history, constitutional features, and lifestyle factors to select remedies.

• Remedy Selection: Remedies were selected through repertorization techniques and homeopathic software, taking into account the miasmatic background and the chronic nature of the illness.

• Potency and Dosage Adjustments: Remedies were prescribed in potencies like 30C, 200C, or LM, adjusted based on the patient’s response and vitality. Dosing intervals ranged from daily to monthly.

• Follow-Up Strategy: Follow-ups (monthly or bimonthly) evaluated symptom changes, emotional states, lab reports, and side effects. Remedies were adjusted based on

• Hering’s Law of Cure and response patterns.

• In chronic cases, complementary lifestyle and dietary recommendations were provided to support immune regulation and general well-being.

  Data Collection and Assessment Measures

  Data were collected from:

• Clinical Records: Baseline and follow-up clinical assessments documented by homeopaths.

• Laboratory Tests: Including RA factor, ANA, C3/C4, CRP, full blood count, renal function, liver function, lipid profile, urine test, and thyroid antibodies.

• Patient Reports: Feedback on functional improvement, emotional well-being, and symptom relief.

  Evaluation Metrics and Analysis Framework

  A mixed-methods framework was used to track patient progress and assess clinical outcomes. The following metrics were employed:

• Symptom Relief: Joint pain, swelling, gastrointestinal issues, skin eruptions, and cough were quantified with numeric pain scales and improvement percentages (>50%).

• Laboratory Biomarkers: Objective measures like creatinine, eGFR, ANA, RA factor, CRP, and TRAb were reviewed at regular intervals.

• Emotional and Functional Well-Being: Diaries and family observations assessed emotional resilience, behavioral changes, sleep quality, fatigue, and mood stability.

• Lifestyle and Dietary Adherence: Commitment to lifestyle changes, including weight management, physical activity, and diet, were tracked.

• Direction of Cure and Symptom Evolution: The reappearance of old symptoms (e.g., skin conditions) was interpreted via Hering’s Law of Cure, indicating positive prognostic value.

• Causality Assessment: The Modified Naranjo Criteria for Homeopathy (MONARCH) was used to assess whether clinical improvements were attributable to homeopathic treatment.

  Safety Monitoring: Aggravations, old symptoms, and adverse effects were recorded and analysed. Safety was also assessed through lab markers and patient-reported remedy tolerance.

  Results

  This section summarises key outcomes from five patients treated with individualised homeopathy, showing clinical and lab improvements over 2–5 years.

  Case Descriptions

  The five cases cover diverse autoimmune conditions—rheumatoid arthritis, Graves’ disease, anemia, mixed connective tissue disease (MCTD), and associated emotional trauma. Each case involved tailored homeopathic regimens aligned with patient symptoms and their unique vitality level. Table 1 summarises demographic data, presenting symptoms, remedies administered, treatment duration, and therapeutic outcomes. Table 2 presents visual documentation of cutaneous symptom progression in Cases #1, #3, #4, and #5. Serial photographs captured at various stages of treatment illustrate notable improvements in skin inflammation, lesion severity, and overall dermal integrity.

  Symptom Improvement Highlights

  Over all five cases, clinical records and patient-reported outcomes demonstrated clear therapeutic effects:

• Pain Reduction: RA and MCTD cases reported pain scores decreasing from 8–9/10 to 2–3/10 within 12–18 months.

• Skin Regeneration: Notably in Case #4, skin eruptions healed in tandem with normalised immune markers and kidney function.

• Emotional Stabilisation: Cases #2, #3, and #5 reported marked emotional recovery, including reduced anxiety, insomnia, and grief.

• Systemic Symptom Relief: Case #5 (thyroid) and Case #3 (gastric symptoms) highlighted broad systemic relief, such as improved digestion, eye symptoms, and energy levels.

  Laboratory Biomarker Improvements

  Objective lab results corroborated symptomatic recovery:

• RA Factor: Normalised in Cases #1, #2 and #3.

• ANA and Immune Modulation: ANA became negative in Case 3 and significantly reduced in Case

  4. Complement factors stabilised.

• eGFR: Normalised in Case #4

• Thyroid Antibodies: TRAb and TSH normalised in Case 5, indicating remission of Graves’ disease.

  Table 1: Summary of Homeopathic Treatment Outcomes in Autoimmune Disorders (Cases #1–

  #5)

  
  

  Case	Demo- graphi cs	AI Conditi on	Initial Symptom s	Key Remedi es Used	Durati on (Month s)	Clinical Progress	Key Outcomes	Current Status	Key Notes
  #1	Female , 52 years old, Office Manag er	Chronic RA with Eczema	Left ankle sprained pain (both upper and lower extremitie s)- began after chronic skin eruptions suppresse d by topical application of steroid 12 months ago; then RA diagnosis followed. Sleep disturbed due to anxiety of health.	Sulphur 30C, Phospho rus 30C	48	RF: 211 → 17 IU/ml (Normalised). Acute urticaria (old symptom) recurrence after vaccination is similar to previous symptoms, but no new complications noted. Multiple Acute fever episodes (fluctuated around 38°C, resolved by own without medication). The patient’s mental state is stable.	RA remission. Eczema resolved. Sleep improved.	Overall chronic complaint s are stable. No recurrenc e of autoimmu ne complicati on. Mental & emotional state is good. Monitored without new prescripti ons.	Acute (fever) during chronic homeopathic treatment is good sign of innate immunity healing response & progress toward balance (Chabanov, Tsintzas & Vithoulkas, 2018; Mahesh et al., 2021)
  #2	Female , 53 years old, Accoun t adminis trator	Chronic RA with anaemi a	Chronic Anaemia. Pre- menopaus e symptoms (mammae pain, chest constrictio n, headache, mouth ulcers, hot flushes), Urinary Tract infection with urine test positive. Pulsating sensation along chest with suffocatio n feeling in throat area. Loquacity during anger.	Lachesis 200C, Chelidon ium 200C, Arsenicu m 200C	36	RF: 238 → <20 IU/ml (Normalised). Blood profile normalised- Haemoglobin: 115g/L  13.2g/L RBC: 5.72x10^12/L 4.4 x10^12/L. MCV: 67 Fl 96Fl. MCH: 2030pg. MCHC: 300320g/L. RDW: 19.0% 13.4%. Yeast in Urine sampling normalised. Multiple episodes of fever were resolved spontaneously .	RA resolved, anaemia improved, emotional balance achieved. Old symptoms of fastidious- ness (cleaning mania) reappearing align with the direction of healing as in accordance to Law of Herring (Vithoulkas & Van Woensel, 2010).	Full recovery with RA negative. Ongoing observati on without new prescripti on.	Acute (fever) conditions during homeopathic treatment for chronic ailments often signify a good prognosis, reflecting the innate healing response and progress toward balance (Chabanov, Tsintzas & Vithoulkas, 2018; Mahesh et al., 2021).
  #3	Female , 61	Chronic RA with severe	Rheumato id arthritis for 10	Arsenicu m 200C, Graphite	24	ANA: 1:320  non-reactive	ANA Levels remain negative	No Gastritis.	According to Vithoulkas and

  	years old, House- wife	gastritis & dermatit is	years, with increased joint pain and stiffness over the past 3 years. In the last 6 months, severe gastritis with bloating and acidity required weekly hospital visits. Also suffers from chronic candidiasi s, dermatitis. Emotional trauma is due to a painful fallout with her daughter.	s 200C, Petroleu m 30C, Rhus tox 0/1		RF: 33.7 IU/ml12.7 IU/ml (Normalised). C3: 95 mg/d (Stable) C4: 22 mg/dl (Stable) Gastric symptoms resolved completely 100% within one week of starting the remedy, allowing the patient to stop all gastritis medications. Dermatitis worsened within six months after the remedy, but with improved ANA levels. Over the following 12 months, the condition gradually improved by > 80%; candidiasis tested Negative.	and stable in the last 12 months. Mouth ulcers & vaginal discharge due to candidiasis were resolved. Improved emotional stability.	No joint symptom s. The skin eruptions initially aggravate d, then gradually improved and remain mild, with ongoing observati on under the remedy Rhus tox 0/1.	Chabanov, (2023), during homeopathic treatment, a temporary aggravation of symptoms followed by their amelioration is considered a possible sign of cure. Emotional and mental health are steadily improving, with the patient focusing on repairing personal relationship.
  #4	Male, 53 years old, System Analyst	MCTD with Chronic Kidney Disease (CKD) Stage 4	Arthritis and gout flare-up presenting as joint pain localised in the big toe; CKD with renal dysfunctio n. Skin issues, including rashes, redness, swelling, and intense itchiness. Described as fastidious, with obsessive- compulsiv e tendencie s, impulsive and	Arsenicu m 200C, Sulphur 200C, Thuja 30C	36	eGFR: 26% → >90% (improved from CKD Stage 4 to normalised). Gout attacks reduced in frequency by approximately 70% following the first remedy, allowing immediate discontinuatio n of painkillers, with no further attacks reported in the six months since treatment began. ANA 1:320- 1:160 (improved)	ANA reduced, renal markers normalised, Skin condition improved 90% Mental & emotional state improved first, followed by a temporary aggravation of physical symptoms, which later subsided with overall improvemen t	Energetic, compliant with lifestyle. Significan t improvem ent in joint pain. Regular monitorin g recomme nded. Improvem ent in CKD, along with the return of old skin eruptions —initially presentin g as increased redness but reduced itching— suggests a favorable healing	Physical symptoms, like skin issues, worsened, while mental and emotional health improved, shifting from egoism to becoming a loving husband. This suggests a positive prognosis, indicating a shift from mental- emotional derangement to physical healing (Vithoulkas & Chabanov, 2023).

  			frequent irritability, as noted by his wife.					response, consistent with Hering’s Law of Cure.
  #5	Female , 50 years old, Financi al Planner	Graves’ Disease with emotion al trauma	Bulging eyes with redness, dryness, difficulty focusing, pain, and swelling (chemothe rapy advised by UMSC but declined). Marked weight loss and emaciatio n. Insomnia, anxiety with palpitation s, and episodes of hysterical & impulsive behaviour; emotional trauma from a broken marital relationshi p.	Causticu m 200C, Zincum 200C, Ignatia 1M	60	TRAb:10.2 IU/L  <1.75 IU/L (Non- Reactive) T3: 5 ng/m1.8 ng/mL (Normal: 0.8 - 2 ng/mL) - normalised T4: 48 µg/dL21.49 µg/dL (Normal: 5.0 - 12.0 µg/dL) – improved TSH (Thyroid Stimulating Hormone): 0.001 µIU/mL 0.25 µIU/L (Normal: 0.4 - 4.0 µIU/mL)- improved	Graves' disease in remission, with improved emotional health. Complete resolution of heart palpitations. Significant improvemen t in both emotional (hysterical- impulsive) with insomnia resolved and mental and emotional stability achieved.	Emotional distress from relationsh ip issues did not impact thyroid function physiologi cally; grief was managed and stabilised with Ignatia 1M. Mild thyroid fluctuatio ns occurred without complicati ons or hyperthyr oid symptom s. On-going observati on and regular follow up.	Mild acute cystitis with low-grade fever (37.8°C), after 20 years without acute episodes, suggests a good prognosis and reflects the body's renewed vitality (Chabanov, Tsintzas & Vithoulkas, 2018; Mahesh et al., 2021). Healing is indicated by the reappearanc e of old skin eruptions, which aligns with the Law of Herring.

  Visual representations were used to document the cutaneous symptom progress in Cases #1, #3, #4, and #5. These included serial photographs at different treatment stages to demonstrate improvements in inflammation, eruptions, and overall skin integrity.

  Case 1: Chronic RA with Eczema

  Key Summary:

  • Treated initially with Phosphorus 30C for severe eczema, RA symptoms, and anxiety.

  • RA Factor dropped significantly. Eczema flared post-vaccination but resolved.

  • Currently in remission, no relapses of eczema, skin and sleep stable (Figure 1a, 1b, 1c, 1d).

    
    

    

    Figure 1a: Skin Complication (Initial consultation)

    
    

    

    Figure 1b: 3-6 Months After Consultation

    

    Figure 1c: 12 Months After Remedy (Relapsed of Skin Complication After Vaccination)

    Case 3: Chronic RA with severe gastritis & dermatitis

    Key Summary:

    • Initial symptoms: joint pain, skin eruptions, fungal infection, gastric discomfort, emotional instability.

    • Treated with Arsenicum 200C, then Graphites, Mezereum, Petroleum, and Rhus tox 0/1 as symptoms evolved.

    • Gastric and joint pain resolved fully by 24 months; dermatitis worsen initially and then improved by 80% (Figure 2a, 2b, 2c).

      
      

      

      Figure 2a: Skin Complication (Initial Consultation)

      

      Figure 2b: 3-6 Months After Remedy

      
      

      

      Figure 2c: 24 Months After Remedy

      Case 4: MCTD with CKD Stage 4

      Key Summary:

  • Gout attacks are fully resolved.

  • eGFR improved significantly, rising from 26% to over 90%.

  • Skin symptoms initially flared with the return of old eruptions between 3–6 months, coinciding with emotional improvement, gout remission, and kidney recovery; gradual skin healing reached 90% by month 9.

  • ANA levels remained stable. Patients appeared energetic and remained committed to lifestyle modifications (Figure 3a, 3b).

    

    Figure 3a: Skin Complication (Initial Consultation)

    

    Figure 3b: 3-9 Months After Remedy

    Case 5: Graves’ Disease with emotional trauma

    Key Summary:

  • Initial bulging eye symptoms improved significantly within 3 months and stabilised by 12 months, remaining steady up to 60 months.

  • Hyperthyroid symptoms, including weight loss, emaciation, and insomnia, gradually resolved over 12 months and remained stable thereafter.

  • TRAb levels normalised after 12 months of treatment.

  • Emotional fluctuations continued due to spouse conflicts and high work stress, but Graves' symptoms remained stable with no flare-ups. Emotional resilience improved with Ignatia from months 18-24 and remained stable for over three years (Figure 4).

    
    

    

    Figure 4: Overview Progress of Grave Disease’s Eye Symptom

    Interpretation from the Classical Homeopathy Framework

    The clinical outcomes observed in this case series align with foundational principles of classical homeopathy, such as the Law of Similars, Direction of Cure, Law of Simplex (Minimal Dose), and Levels of Health. Additionally, emotional healing preceding physical recovery and responses consistent with Hering’s Law of Cure were evident across cases.

    Law of Similars: Homeopathy relies on the principle that a substance causing symptoms in a healthy person can trigger healing in someone with similar symptoms. Remedies in these cases were chosen based on the patient’s symptoms and remedy characteristics, leading to improved immunity and resolution of chronic conditions.

    Direction of Cure (Hering’s Law): In classical homeopathy, healing follows a predictable pattern known as Hering’s Law of Cure: it progresses from vital organs to less critical parts, from within outward, from top to bottom, and in reverse order of symptom appearance. The temporary return of old symptoms— such as skin eruptions or fever—is not a setback but a sign of deeper healing and restored balance in the vital force. In the cases studied:

• Cases #1, #2, #3, #4, and #5 showed movement from chronic inflammatory states toward more stable health.

• Case #4 reflected kidney function improvement and lowered systemic inflammation.

• Cases #1, #2, and #5 had acute responses like fever, indicating a reawakened immune system.

• Cases #1, #3, and #4 experienced return of old skin issues, aligning with the expected healing direction.

• Temporary skin aggravations in several cases illustrated the law in action and the depth of constitutional healing, addressing both physical and emotional levels.

  Levels of Health (Vithoulkas & Van Woensel, 2010): The Levels of Health model classifies individuals based on vitality and chronic disease tendencies. Progression toward higher health levels suggests enhanced resilience：

• Cases #1, #2, and #3 showed improvement in both emotional and physical health, aligning with the model of integrated healing.

• Case #4, renal function improvement and emotional balance indicated an upward shift in health.

• Case #5’s remission of autoimmune hyperthyroidism and emotional stability further signified holistic health restoration.

Emotional Healing as a Catalyst for Physical Recovery: Homeopathy often views emotional disturbances as precursors to physical ailments. In these cases, emotional resolution (e.g., anxiety, irritability) coincided with physical symptom reversal, demonstrating the mind-body synergy in healing.

Emerging Themes and Observations

A reflection on these cases reveals recurring patterns that emphasise the integrative and patient- centered nature of classical homeopathy.

Multidimensional Healing Trajectories: Recovery was not limited to one organ system. For example, Case #3 showed concurrent improvement in digestive issues, skin problems, and emotional stability, emphasising the interconnectedness of body and mind.

Innate Shift Toward Healthier Habits: As vitality improved, patients spontaneously adopted healthier habits. Better sleep routines and dietary awareness, indicating that restored balance fosters self-care.

Restoration of Immune Balance: Homeopathic treatment seemed to recalibrate the immune system rather than suppress it with lab markers (e.g., RF, ANA, TRAb, C3/C4) showing improvement, signaling immune rebalancing.

Emotional Recovery as a Gateway to Physical Healing: In all cases, emotional resolution preceded physical improvement. This pattern reinforces the idea that emotional well-being is foundational for physiological recovery, particularly in chronic disease.

Long-Term Stability and Self-Regulation: A promising outcome was the reduction in reliance on conventional medications, coupled with enhanced vitality and fewer acute episodes. This suggests improved immune defense and greater systemic self-regulation over time. These themes demonstrate how homeopathy, practiced according to classical principles, supports deep, integrative healing.

By addressing physical, emotional, and behavioral dimensions, it promotes sustainable healt h, reinforcing homeopathy’s value as a holistic approach for chronic, complex conditions.

Discussion

The following section explores key insights drawn from the clinical outcomes and patterns observed in these five autoimmune cases.

Interpretation of Findings

The findings offer insights into the role of individualised homeopathy in managing autoimmune and chronic inflammatory conditions. Cases involving rheumatoid arthritis (RA), dermatitis, and Graves’ disease showed significant improvements in clinical markers, emotional health, and quality of life, suggesting homeopathy’s immune-modulating potential.

Disease Progression and Immune Modulation: The reduction in RA factor levels—dropping from 211 IU/ml to 17 IU/ml in case #1 and 238 IU/ml to below 20 IU/ml in case #2—reflects a clinical turnaround.

These results resonate with evidence suggesting homeopathy restores immune equilibrium, not merely suppresses symptoms (Vithoulkas & Berghian-Grosan, 2020).

Improvements in ANA levels in case #3 and Case #4, and the normalised TRAb in Case #5 further support the hypothesis that individualised homeopathy modulates dysfunctional immune responses.

Symptom Fluctuations and Homeopathic Aggravation: Initial symptom aggravation, such as in case #4, where skin symptoms flared post-Arsenicum administration, is often seen as a positive therapeutic process (Kent, 1897). This was followed by stabilisation of kidney function and reduced gout attacks, demonstrating the value of homeopathic aggravation in achieving deep, systemic healing (Chabanov, Tsintzas & Vithoulkas, 2018).

Emotional and Gastrointestinal Symptoms: Emotional disturbances and gastrointestinal dysfunctions are common in autoimmune disorders. In case #5, anxiety and palpitations were effectively managed with Causticum and Ignatia, leading to systemic improvement. This supports the integrated mind-body approach emphasised in autoimmune disease treatment (Bekarissova, Bekarisov & Bekaryssova, 2019).

Chronic gastrointestinal symptoms in cases #3 and #4 improved with Mezereum, Petroleum, and Rhus toxicodendron, reaffirming the connection between gut health and immune regulation (Tripathy, 2023).

Long-Term Efficacy and Monitoring: Extended follow-ups showed significant improvement in chronic conditions. Case #4 reversed from Stage 4 chronic kidney disease to Stage 1, and case #5 achieved sustained remission of Graves' disease symptoms. These results underscore the importance of precise remedy selection and ongoing monitoring in achieving long-term therapeutic success.

Comparison with Existing Literature

The results resonate with studies supporting homeopathy’s role in autoimmune and chronic inflammatory disorders. Research by Hossain (2024) shows improvements in RA and lupus with individualised homeopathy. Long-term studies on chronic eczema and ulcerative colitis (Patil, 2020) also report significant symptom reductions, reinforcing homeopathy’s potential in offering holistic, individualised treatment.

Clinical Insight

One key insight is that homeopathy provides long-term disease modulation rather than merely symptom suppression. The MONARCH causality assessment (Lamba et al., 2020), summarised in Table 3, further strengthens clinical confidence. Figure 5 shows the high scores (10–11 out of 12) indicate a strong causal relationship between individualised homeopathic treatment and clinical improvement. These outcomes reflect indicators of a true curative response in classical homeopathy and highlight its therapeutic potential in autoimmune disease management.

Table 3: Modified Naranjo Criteria for Homeopathy (MONARCH) – for Causality Evaluation Scores for Cases #1 to #5

(Note: Each criterion is assigned a score (e.g., Yes = 1, No = 0)

Figure 5: Strong Causal Relationship between Homeopathy and Clinical Improvement

Recommendations

To enhance the scientific credibility of homeopathy in treating autoimmune disorders, randomised controlled trials (RCTs) are crucial. While case series and observational studies suggest promising therapeutic effects, only robust RCTs can provide definitive evidence. Key recommendations for future research include:

Expanded Sample Sizes: Many existing studies, including this case series, are limited by small, non- randomised samples. Future studies should include larger patient cohorts to improve external validity and represent a broader spectrum of autoimmune conditions.

Control and Placebo Arms: Well-designed RCTs with appropriate comparators—either standard care or placebo—are essential for controlling confounding variables like natural disease progression and patient expectations.

Standardised Outcome Metrics: Incorporating validated quality-of-life instruments and other objective measures will enable consistent tracking of treatment effects, providing a more objective evaluation of treatment efficacy.

Limitations

While the clinical outcomes are promising, several limitations must be acknowledged. The small sample size restricts the generalisability of the findings, and the absence of a control group makes it challenging to isolate the specific effects of homeopathy. Retrospective data collection may introduce potential biases, while the concurrent use of conventional therapies complicates the attribution of outcomes solely to homeopathy. Furthermore, subjective symptoms were not always assessed using standardised tools, which may affect the objectivity of the results. Future research should aim to overcome these limitations by conducting randomised controlled trials (RCTs) with larger cohorts and employing objective outcome measures to more accurately evaluate homeopathy’s role in the management of autoimmune diseases.

Conclusion

This study evaluated the effectiveness of individualised homeopathic treatment for chronic autoimmune disorders through five case reports. The results suggest that homeopathy can contribute to immune regulation, symptom relief, and overall well-being, with improvements in autoimmune markers, joint flexibility, skin condition, and emotional stability. Personalised homeopathy, aligned with a patient’s unique profile, may complement conventional treatments for autoimmune conditions like rheumatoid arthritis and Graves’ disease. However, the case-based design limits the generalisability of the findings, and further research, particularly randomised controlled trials, is needed to validate these outcomes. An interdisciplinary approach combining homeopathy with conventional medicine could enhance therapeutic synergy and care options.

Given the multifaceted nature of autoimmune diseases and the individualised approach of homeopathy, an integrative, interdisciplinary model of care is essential. Collaboration across medical and research fields will enhance treatment effectiveness and strengthen scientific credibility. Combining the expertise of homeopaths and immunologists could provide a more comprehensive approach to managing autoimmune disorders, with immunologists monitoring immune system behavior and biomarkers while homeopaths offer personalised remedies tailored to each patient’s unique profile. Such collaboration may promote a deeper understanding of how homeopathy influences immune regulation.

Biomedical researchers also have a pivotal role in advancing the evidence base for homeopathy. Their involvement in designing rigorous studies, analysing data, and contextualising results within the broader framework of immunology is critical for validating the clinical impact of homeopathy. Furthermore, interdisciplinary clinical trials that involve both conventional medical experts and homeopathic practitioners can provide a holistic evaluation of outcomes, fostering mutual respect and integration between medical paradigms.

Future studies should also incorporate standardised Patient-Reported Outcome Measures (PROMs) to better capture patients’ experiences. When combined with laboratory tests, these tools can offer a fuller and more objective picture of homeopathy’s effectiveness. Additionally, creating shared data platforms across institutions and research domains will enable more robust evidence generation, making findings more relevant across different autoimmune diseases and patient populations.

Conflict of Interest

The authors affirm that there are no conflicting objectives.

Acknowledgement

The authors would like to thank all the participants involved in this study for their valuable contributions.

References

Ministry of Health Malaysia. (2015). National Health and Morbidity Survey 2015 (Volume IV). https://www.moh.gov.my/moh/resources/NHMS2015-VolumeIV.pdf

Vithoulkas, G., & Van Woensel, E. (2010). Levels of Health. The Second Volume of the Science of Homeopathy. International academy of classical. Homeopathy, 2, 27-66.

Hossain, T. (2024). Impact of high-dilution homeopathic remedies on autoimmune disorders. Journal of Homeopathy Studies, 1(1), 03-06. https://www.homeopathyjournal.com/archives/2024/vol1issue1/PartA/1-1-2- 451.pdf

Lamba, C. D., Gupta, V. K., Van Haselen, R., et al. (2020). Evaluation of the modified Naranjo criteria for assessing causal attribution of clinical outcome to homeopathic intervention. Homeopathy, 109(4), 191–197. https://doi.org/10.1055/s-0040-1701251

Mahesh, S., Mallappa, M., Habchi, O., Konstanta, V., Chise, C., Sykiotou, P., & Vithoulkas, G. (2021). Appearance of acute inflammatory state indicates improvement in atopic dermatitis cases under classical homeopathic treatment: a case series. Clinical Medicine Insights: Case Reports, 14. https://doi.org/10.1177/1179547621994103

Chabanov, D., Tsintzas, D., & Vithoulkas, G. (2018). Levels of health theory with the example of a case of juvenile rheumatoid arthritis. Journal of Evidence-Based Integrative Medicine, 23. https://doi.org/10.1177/2515690X18777995

Tripathy, T. (2023). Bowel nosodes of homoeopathy in colorectal cancer and auto immune, metabolic, neuro psychiatric disorders. Scholars Journal of Applied Medical Sciences, 11(9), 1667-1676. https://doi.org/10.36347/sjams.2023.v11i09.014

Mahmud, Z. M., Aris, T., Syed Mohamed, A. F., Sondi, S., Azman, A. H., Maimunah, A. H., Haniza, M. A., Siti Haslinda, M. D., Zulkarnain, A. K., Zakiah, I., & Wan Zaleha, W. C. (2009). Use of traditional and complementary medicine in Malaysia: A baseline study. Complementary Therapies in Medicine, 17(4), 292–299. https://doi.org/10.1016/j.ctim.2009.04.002

Patil, P.C. (2020). Evaluating the Efficacy of Homeopathic Treatments in the Management of Eczema: A Comprehensive Review. International Journal For Multidisciplinary Research (IJFMR), 6(4). https://doi.org/10.36948/ijfmr.2024.v06i04.24772

Bekarissova, S., Bekarisov, O., & Bekaryssova, D. (2024). An integrated approach to the treatment of rheumatic diseases: the role of psychological interventions. Rheumatology International, 44(12), 2727-2735. https://doi.org/10.1007/s00296-024-05728-9

Vithoulkas, G., & Chabanov, D. (2023). The evolution of miasm theory and its relevance to homeopathic prescribing. Homeopathy, 112(01), 057-064.https://doi.org/10.1055/s-0042-1751257

Vithoulkas, G., & Berghian-Grosan, C. (2020). The spin of electrons and the proof for the action of homeopathic remedies. Journal of Medicine and Life, 13(3), 278. https://doi.org/10.25122/jml-2020-0140